| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
PTEN-induced kinase 1-induced dynamin-related protein 1 Ser637 phosphorylation reduces mitochondrial fission and protects against intestina ischemia reperfusion injury
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wasim Qasim, Yang Li, Rui-Min Sun, Dong-Cheng Feng, Zhan-Yu Wang, De-Shun Liu, Ji-Hong Yao and Xiao-Feng Tian |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81679154 |
| National Natural Science Foundation of China |
81871547 |
|
| Corresponding Author |
Xiao-Feng Tian, MD, PhD, Director, Director, Professor, Surgeon, Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, 467 Zhongshan Road, Shahekou District, Dalian 116023, Liaoning Province, China. txfdl@dmu.edu.cn |
| Key Words |
Intestinal ischemia reperfusion injury; Mitochondrial fission; PTEN-induced putative kinase 1; Dynamin-related protein 1 ser637; Phosphorylation; Apoptosis |
| Core Tip |
PTEN induced kinase 1 (PINK1) is a kind of mitochondrial serine/threonine-protein kinase, which regulates mitochondrial homeostasis through regulating the phosphorylation of target proteins. Depletion of PINK1 has been proved that associated with mitochondrial fragmentation and apoptosis in ischemic model. However, the underlying mechanism has not been clarified. By generating intestinal ischemia reperfusion model in mice and hypoxia/reoxygenation model in Caco-2 cells, we revealed that PINK1 inhibits mitochondrial fission and apoptosis via phosphorylating dynamin-related protein 1 on Ser637. The PINK1/dynamin-related protein 1 pathway may provide a potential target in intestinal ischemia reperfusion injury treatment. |
| Publish Date |
2020-04-21 06:56 |
| Citation |
Qasim W, Li Y, Sun RM, Feng DC, Wang ZY, Liu DS, Yao JH, Tian XF. PTEN-induced kinase 1-induced dynamin-related protein 1 Ser637 phosphorylation reduces mitochondrial fission and protects against intestinal ischemia reperfusion injury. World J Gastroenterol 2020; 26(15): 1758-1774 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i15/1758.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i15.1758 |
