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Articles Published Processes
10/14/2020 1:53:47 PM | Browse: 854 | Download: 2267
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Received |
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2020-03-02 12:19 |
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Peer-Review Started |
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2020-03-02 12:20 |
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To Make the First Decision |
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Return for Revision |
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2020-04-25 21:04 |
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Revised |
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2020-05-18 13:21 |
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Second Decision |
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2020-05-27 09:16 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-05-28 21:31 |
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Articles in Press |
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2020-05-28 21:31 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-06-08 02:39 |
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Typeset the Manuscript |
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2020-10-13 01:32 |
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Publish the Manuscript Online |
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2020-10-14 13:53 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Synergistic anti-liver cancer effects of curcumin and total ginsenosides
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhe Deng, Xiao-Yan Xu, Fenny Yunita, Qing Zhou, Yong-Rong Wu, Yu-Xing Hu, Zhi-Qi Wang and Xue-Fei Tian |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81473617 |
| Science and Technology Department of Hunan Province |
2017SK50310 |
| Hunan Education Department’s Science & Research Project |
16K066 |
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| Corresponding Author |
Xue-Fei Tian, PhD, Professor, College of Integrated Chinese and Western Medicine, Hunan University of Chinese Medicine, 300 Xueshi Road, Yuelu District, Changsha 410208, Hunan Province, China. 003640@hnucm.edu.cn |
| Key Words |
Total ginsenosides; Curcumin; Liver cancer; Immune; Inflammation; Programmed cell death 1 ligand 1 |
| Core Tip |
The occurrence and development of liver cancer can drive by inflammation, the imbalance of cell-mediated immune mechanism also plays an important role. Controlling inflammatory drive and restoring cellular immunity are new targets for the treatment of liver cancer. Here, we combined curcumin, an effective drug that controls inflammation, with total ginsenosides which enhances immune function, We confirmed that the two drugs have synergistic anti-liver cancer effect on a mouse model of subcutaneous, and they mainly play the role in molecular mechanism through programmed cell death 1 ligand 1 and NF-κB signaling pathway. These findings providing a new idea for combined drug therapy for liver cancer. |
| Publish Date |
2020-10-14 13:53 |
| Citation |
Deng Z, Xu XY, Yunita F, Zhou Q, Wu YR, Hu YX, Wang ZQ, Tian XF. Synergistic anti-liver cancer effects of curcumin and total ginsenosides. World J Gastrointest Oncol 2020; 12(10): 1091-1103 |
| URL |
https://www.wjgnet.com/1948-5204/full/v12/i10/1091.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v12.i10.1091 |
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