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3/28/2020 1:10:02 PM | Browse: 1274 | Download: 2579
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Received |
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2019-12-19 18:09 |
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Peer-Review Started |
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2019-12-19 18:09 |
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First Decision by Editorial Office Director |
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2020-01-12 06:43 |
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Return for Revision |
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2020-01-12 06:43 |
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Revised |
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2020-03-10 09:57 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2020-03-20 09:04 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2020-03-22 01:55 |
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Articles in Press |
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2020-03-22 01:55 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-03-27 09:20 |
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Publish the Manuscript Online |
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2020-03-28 13:10 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Carrier frequency of HLA-DQB1*02 allele in patients affected with celiac disease: A systematic review assessing the potential rationale of a targeted allelic genotyping as a first-line screening
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Dimitri Poddighe, Chiara Rebuffi, Annalisa De Silvestri and Cristina Capittini |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Nazarbayev University Faculty Development Competitive Research Grant 2020-2022 |
240919FD3912 |
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| Corresponding Author |
Dimitri Poddighe, MD, MSc, Assistant Professor, Department of Medicine, School of Medicine, Nazarbayev University, Kerei-Zhanibek Street 5/1, Nur-Sultan 010000, Kazakhstan. dimitri.poddighe@nu.edu.kz |
| Key Words |
Celiac disease; Children; HLA-DQB1*02; DQ2 heterodimer; Screening; Systematic review |
| Core Tip |
It is well known that HLA-DQ genotyping is useful to assess the individual susceptibility to celiac disease (CD) with very high - if not absolute – discriminatory power: Indeed, it is very unlikely that individuals who do not carry specific HLA-DQ alleles coding MHC-DQ2 and MHC-DQ8 heterodimers, may develop CD. Here, we aim at providing further evidence of the specific epidemiological importance of HLA-DQB1*02 allele in the population of CD patients. Briefly, based on 38 original articles that we included in this systematic review (which provided a pool of 4945 HLA-DQ genotyped CD patients, overall), we could find a very high carrier frequency of the HLA-DQB1*02 allelic variant. Indeed, > 95%-96% of CD patients resulted to carry at least one copy of the HLA-DQB1*02 allele. This knowledge might be exploited to consider a cost-effective and widened screening approach: If a sustainable strategy could be implemented through a low-cost targeted genetic test for CD, an appropriate algorithm for serological screening in individuals resulting to be genetically predisposed to CD, might be considered. |
| Publish Date |
2020-03-28 13:10 |
| Citation |
Poddighe D, Rebuffi C, De Silvestri A, Capittini C. Carrier frequency of HLA-DQB1*02 allele in patients affected with celiac disease: A systematic review assessing the potential rationale of a targeted allelic genotyping as a first-line screening. World J Gastroenterol 2020; 26(12): 1365-1381 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i12/1365.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i12.1365 |
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