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Publication Name World Journal of Gastrointestinal Pathophysiology
Manuscript ID 53498
Country/Territory Spain
2019-12-30 14:52
Peer-Review Started
2019-12-30 14:53
To Make the First Decision
2020-02-11 00:30
Return for Revision
2020-02-13 05:21
2020-02-27 15:15
Second Decision
2020-03-30 14:59
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-03-30 20:59
Articles in Press
2020-03-30 20:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2020-05-09 10:30
Publish the Manuscript Online
2020-05-12 03:08
ISSN 2150-5330 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Microbiology
Manuscript Type Retrospective Cohort Study
Article Title Evaluation of bacterial biomarkers to aid in challenging inflammatory bowel diseases diagnostics and subtype classification
Manuscript Source Invited Manuscript
All Author List Mireia Lopez-Siles, Xavier Aldeguer, Miriam Sabat-Mir, Mariona Serra-Pagès, Sylvia H Duncan, Harry J Flint, L Jesús Garcia-Gil and Margarita Martinez-Medina
Author(s) ORCID Number
Mireia Lopez-Siles http://orcid.org/0000-0002-5805-8446
Xavier Aldeguer http://orcid.org/0000-0003-4597-8339
Miriam Sabat-Mir http://orcid.org/0000-0002-0130-7173
Sylvia H Duncan http://orcid.org/0000-0002-4903-0978
Harry J Flint http://orcid.org/0000-0003-2116-0188
L Jesús Garcia-Gil http://orcid.org/0000-0002-5064-8361
Margarita Martinez-Medina http://orcid.org/0000-0003-0177-3307
Funding Agency and Grant Number
Funding Agency Grant Number
Spanish Ministry of Education and Science SAF2010-15896
Spanish Ministry of Education and Science SAF2013-43284-P
Spanish Ministry of Education and Science SAF2017-82261-P
Corresponding Author Margarita Martinez-Medina, PhD, Associate Professor, Laboratory of Molecular Microbiology, Biology Department, Universitat de Girona, Carrer de Maria Aurèlia Capmany, 40, Girona 17003, Spain. marga.martinez@udg.edu
Key Words Crohn’s disease; Ulcerative colitis; Inflammatory bowel disease; Diagnostic tests; Faecalibacterium prausnitzii; Escherichia coli
Core Tip This manuscript evaluates the usefulness of new indexes calculated from the quantification of Faecalibacterium prausnitzii, its phylogroups, and Escherichia coli as biomarkers to assist in challenges of inflammatory bowel disease diagnostics. Firstly, discrimination between inflammatory bowel disease and other intestinal disorders was tested. We present indices to distinguish colorectal cancer from inflammatory bowel disease, especially from subjects with ulcerative colitis. This is of significance given the association between chronic inflammation and the risk of colorectal cancer. In contrast, the proposed indices featured limited performance for discriminating inflammatory bowel disease from irritable bowel syndrome. Secondly, we approach if these biomarkers would be useful to discriminate within inflammatory bowel disease subtypes. We show here good biomarkers to differentiate inflammatory bowel disease subtypes of shared disease location, which may assist in monitoring the risk of progression of the inflamed area. Their application in non-invasive faecal samples is also demonstrated.
Publish Date 2020-05-12 03:08
Citation Lopez-Siles M, Aldeguer X, Sabat-Mir M, Serra-Pagès M, Duncan SH, Flint HJ, Garcia-Gil LJ, Martinez-Medina M. Evaluation of bacterial biomarkers to aid in challenging inflammatory bowel diseases diagnostics and subtype classification. World J Gastrointest Pathophysiol 2020; 11(3): 64-77
URL https://www.wjgnet.com/2150-5330/full/v11/i3/64.htm
DOI https://dx.doi.org/10.4291/wjgp.v11.i3.64
Full Article (PDF) WJGP-11-64.pdf
Full Article (Word) WJGP-11-64.docx
Manuscript File 53498-Review.doc
Answering Reviewers 53498-Answering reviewers.pdf
Audio Core Tip 53498-Audio core tip.mp3
Biostatistics Review Certificate 53498-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 53498-Conflict-of-interest statement.pdf
Copyright License Agreement 53498-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 53498-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 53498-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 53498-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 53498-Language certificate.pdf
Supplementary Material 53498-Supplementary material.pdf
Peer-review Report 53498-Peer-review(s).pdf
Scientific Misconduct Check 53498-Scientific misconduct check.pdf
Scientific Editor Work List 53498-Scientific editor work list.pdf