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Articles Published Processes
4/30/2020 3:27:12 PM | Browse: 995 | Download: 2704
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Received |
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2019-12-28 09:08 |
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Peer-Review Started |
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2019-12-28 09:08 |
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To Make the First Decision |
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2020-01-16 03:58 |
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Return for Revision |
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2020-01-16 04:18 |
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Revised |
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2020-01-21 03:39 |
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Second Decision |
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2020-04-03 12:57 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-04-04 02:46 |
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Articles in Press |
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2020-04-04 02:46 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-04-17 05:50 |
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Typeset the Manuscript |
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2020-04-28 01:14 |
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Publish the Manuscript Online |
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2020-04-30 15:27 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Serotonin transporter and cholecystokinin in diarrhea-predominant irritable bowel syndrome: Associations with abdominal pain, visceral hypersensitivity and psychological performances
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Geng Qin, Yu Zhang and Shu-Kun Yao |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Key Technology Support Program during “12th Five-Year Plan” period of China |
2014BAI08B00 |
| Leap-forward Development Program for Beijing Biopharmaceutical Industry (G20) |
Z171100001717008 |
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| Corresponding Author |
Shu-Kun Yao, MD, PhD, Professor, Department of Gastroenterology, China-Japen Friendship Hospital, 2nd Yinghua East Road, Chaoyang District, Beijing 100029, China. shukunyao@126.com |
| Key Words |
Irritable bowel syndrome; Abdominal pain; Visceral hypersensitivity; Psychological performances; Serotonin transporter; Cholecystokinin |
| Core Tip |
This study comprehensively evaluated the symptoms, mental state and visceral sensitivity of patients with diarrhea-predominant irritable bowel syndrome (IBS-D), and further explored serotonin transporter (SERT) and cholecystokinin (CCK) levels in IBS-D patients diagnosed by Rome IV and analyzed their associations with abdominal pain, visceral hypersensitivity and psychological performances. The results showed that the expression of CCK was positively correlated with abdominal pain, while the expression of SERT was negatively correlated with abdominal pain, anxiety and depression, which revealed that SERT and CCK might be involved in the pathogenesis of IBS-D and might provide a new potential way to find a more specific and effective therapeutic target. |
| Publish Date |
2020-04-30 15:27 |
| Citation |
Qin G, Yu Y, Yao SK. Serotonin transporter and cholecystokinin in diarrhea-predominant irritable bowel syndrome: Associations with abdominal pain, visceral hypersensitivity and psychological performances. World J Clin Cases 2020; 8(9): 1632-1641 |
| URL |
https://www.wjgnet.com/2307-8960/full/v8/i9/1632.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v8.i9.1632 |
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