Publication Name	World Journal of Hepatology
Manuscript ID	5352
Country	Japan

Received	2013-09-02 07:52
Peer-Review Started	2013-09-02 17:26
First Decision by Editorial Office Director
Return for Revision	2013-09-29 18:17
Revised	2013-10-07 05:19
Publication Fee Transferred
Second Decision by Editor	2013-11-04 16:23
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2013-11-05 08:35
Articles in Press
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-11-21 14:27
Publish the Manuscript Online	2013-11-26 22:03

ISSN	1948-5182 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	IL-28B polymorphisms and treatment response in hepatitis C virus patients with persistently normal alanine aminotransferase
Manuscript Source	Invited Manuscript
All Author List	Tatsuo Miyamura, Tatsuo Kanda, Masato Nakamura, Xia Jiang, Shuang Wu, Shingo Nakamoto, Shigeru Mikami, Nobuo Takada, Fumio Imazeki and Osamu Yokosuka
Funding Agency and Grant Number	Funding Agency Grant Number Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology, Japan Ministry of Health, Labour and Welfare of Japan
Corresponding Author	Tatsuo Kanda, MD, PhD, Associate Professor, Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8677, Japan. kandat-cib@umin.ac.jp
Key Words	Hepatitis C virus; Interleukin 28B; Persistent normal alanine aminotransferase levels; Standard of care; Treatment response
Core Tip	Whether the interleukin 28B (IL-28B) genotype affects the treatment response to peginterferon plus ribavirin in hepatitis C virus (HCV)-infected patients with persistently normal alanine aminotransferase (PNALT) is unclear. We examined the association between the IL-28B genotype and treatment response in HCV-infected patients with PNALT. Opinions about the appropriate treatment method for HCV-infected patients with PNALT differ. In the present study, we found that IL-28B rs8099917 TT was associated with SVR in HCV genotype 1-infected Asian patients with PNALT. The determination of IL-28B genotype is important for the successful treatment of HCV genotype 1-infected patients with PNALT.
Publish Date	2013-11-26 22:03
Citation	Miyamura T, Kanda T, Nakamura M, Jiang X, Wu S, Nakamoto S, Mikami S, Takada N, Imazeki F, Yokosuka O. IL-28B polymorphisms and treatment response in hepatitis C virus patients with persistently normal alanine aminotransferase. World J Hepatol 2013; 5(11): 635-641
URL	http://www.wjgnet.com/1948-5182/full/v5/i11/635.htm
DOI	http://dx.doi.org/10.4254/wjh.v5.i11.635

Full Article (PDF)	WJH-5-635.pdf
Manuscript File	5352-Review.doc
Answering Reviewers	5352-Answering reviewers.pdf
Copyright License Agreement	5352-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	5352-Language certificate.pdf
Peer-review Report	5352-Peer review(s).pdf
Scientific Editor Work List	5352-Scientific editor work list.doc