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Articles Published Processes
7/17/2020 3:31:26 AM | Browse: 803 | Download: 1390
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Received |
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2019-12-31 13:33 |
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Peer-Review Started |
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2019-12-23 16:15 |
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To Make the First Decision |
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Return for Revision |
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2020-04-03 20:02 |
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Revised |
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2020-04-25 02:04 |
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Second Decision |
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2020-05-27 00:59 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-05-27 17:25 |
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Articles in Press |
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2020-05-27 17:25 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-06-10 06:00 |
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Typeset the Manuscript |
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2020-07-16 00:38 |
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Publish the Manuscript Online |
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2020-07-17 03:31 |
| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Behavioral Sciences |
| Manuscript Type |
Basic Study |
| Article Title |
Comparison of three administration modes for establishing a zebrafish seizure model induced by N-Methyl-D-aspartic acid
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Xin-Yi Long, Wang Shuang, Zhi-Wen Luo, Xu Zhang and Hong Xu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81760216 |
| National Natural Science Foundation of China |
81160144 |
| National Natural Science Foundation of China |
31171044 |
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| Corresponding Author |
Hong Xu, PhD, Professor, Institute of Life Science, Nanchang University, Xuefu Avenue 1299, Nanchang 330031, Jiangxi Province, China. xuhong@ncu.edu.cn |
| Key Words |
Seizure; Zebrafish; N-Methyl-D-aspartic acid; Administration modes; Resveratrol; MK-801 |
| Core Tip |
This is the first study systematically comparing the three main administration modes of zebrafish to establish a seizure model. A newly developed zebrafish model with acute and sustained experimental epileptic behavior enables us to study and identify potential mechanisms and screen anti-epileptic drugs. Direct administration of N-Methyl-D-aspartic acid stimulates abnormal excitations of brain nerve cells to simulate epileptic seizures. This study demonstrates that intravitreal injection can be used to establish an acute epilepsy model and immersion can be used as a persistent epilepsy model. The protective effects of resveratrol and MK-801 on the epileptic process have also been confirmed, which may have clinical application value. |
| Publish Date |
2020-07-17 03:31 |
| Citation |
Long XY, Wang S, Luo ZW, Zhang X, Xu H. Comparison of three administration modes for establishing a zebrafish seizure model induced by N-Methyl-D-aspartic acid. World J Psychiat 2020; 10(7): 150-161 |
| URL |
https://www.wjgnet.com/2220-3206/full/v10/i7/150.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v10.i7.150 |
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