Publication Name	World Journal of Gastroenterology
Manuscript ID	5356
Country	China

Received	2013-09-02 08:07
Peer-Review Started	2013-09-02 18:12
To Make the First Decision	2013-09-27 16:56
Return for Revision	2013-09-29 10:26
Revised	2013-10-24 11:14
Second Decision	2013-12-05 19:24
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-12-06 11:58
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-01-04 19:34
Typeset the Manuscript	2014-01-24 19:33
Publish the Manuscript Online	2014-02-17 14:01

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Protective role of hydrogen-rich water on aspirin-induced gastric mucosal damage in rats
Manuscript Source	Invited Manuscript
All Author List	Jing-Yao Zhang, Qi-Fei Wu, Yong Wan, Si-Dong Song, Jia Xu, Xin-Sen Xu, Hu-Lin Chang, Ming-Hui Tai, Ya-Feng Dong and Chang Liu
Funding Agency and Grant Number
Corresponding Author	Chang Liu, MD, PHD, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University Health Science Center, 277 West Yanta Road, Xi’an 710061, Shaanxi Province, China. liuchangdoctor@163.com
Key Words	Hydrogen; Aspirin; Gastric lesion; Oxidative stress; Cytokines; Cyclooxygenase 2
Core Tip	Aspirin is one of the most widely used medicines, but can cause adverse side effects of gastric injury. Hydrogen has been found to have powerful anti-oxidant and anti-inflammatory effects. We investigated the protective role of hydrogen-rich water on aspirin-induced gastric mucosal damage in rats. We found that hydrogen could alleviate the aspirin-induced gastric lesions by inhibiting the oxidative stress, inflammatory reaction and reducing the Cyclooxygenase 2 in the gastric tissues. This may provide a potential therapy for the adverse effects of aspirin.
Publish Date	2014-02-17 14:01
Citation	Zhang JY, Wu QF, Wan Y, Song SD, Xu J, Xu XS, Chang HL, Tai MH, Dong YF, Liu C. Protective role of hydrogen-rich water on aspirin-induced gastric mucosal damage in rats. World J Gastroenterol 2014; 20(6): 1614-1622
URL	http://www.wjgnet.com/1007-9327/full/v20/i6/1614.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i6.1614

Full Article (PDF)	WJG-20-1614.pdf
Full Article (Word)	WJG-20-1614.doc
Manuscript File	5356-Review.docx
Answering Reviewers	5356-Answering reviewers.pdf
Copyright License Agreement	5356-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	5356-Language certificate .pdf
Peer-review Report	5356-Peer review(s).pdf
Scientific Editor Work List	5356-Scientific editor work list.doc