Publication Name	World Journal of Gastroenterology
Manuscript ID	5368
Country	China

Received	2013-09-03 10:10
Peer-Review Started	2013-09-03 14:34
First Decision by Editorial Office Director
Return for Revision	2013-09-29 10:27
Revised	2013-10-11 01:55
Publication Fee Transferred
Second Decision by Editor	2013-11-04 17:27
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2013-11-05 10:02
Articles in Press
Edit the Manuscript by Language Editor	2013-11-15 19:34
Typeset the Manuscript	2013-12-18 13:30
Publish the Manuscript Online	2014-01-14 20:11

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Meta-Analysis
Article Title	TNF-α-308 polymorphism and risk of digestive system cancers: A meta-analysis
Manuscript Source	Invited Manuscript
All Author List	Xu-Feng Guo, Jun Wang, Shi-Jie Yu, Jia Song, Meng-Yao Ji, Zhuo Cao, Ji-Xiang Zhang, Jing Wang and Wei-Guo Dong
Funding Agency and Grant Number
Corresponding Author	Dr. Wei-Guo Dong, Department of Gastroenterology, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan 430060, Hubei Province, China. dwg@whu.edu.cn
Key Words	Tumour necrosis factor alpha; rs1800629; Polymorphism; Digestive system cancer; Meta-analysis; Association
Core Tip	Genetic polymorphisms contribute to the risk of human malignant tumours. Many studies have reported the relationship between the tumour necrosis factor alpha-308 (TNF-α-308) gene polymorphism and risk of digestive system cancers. However, the results of these studies are inconsistent and contradictory. In this meta-analysis, our results suggest that the TNF-α-308 polymorphism is significantly associated with the risk of gastric and hepatocellular carcinomas in the Asian population (dominant model: 95%CI: 1.02-1.34, P < 0.05 and 95%CI: 1.20-2.54, P < 0.05, respectively). This finding indicates that certain polymorphisms and mutations at TNF-α-308 may increase susceptibility to digestive system cancers.
Publish Date	2014-01-14 20:11
Citation	Guo XF, Wang J, Yu SJ, Song J, Ji MY, Cao Z, Zhang JX, Wang J, Dong WG. TNF-a-308 polymorphism and risk of digestive system cancers: A meta-analysis. World J Gastroenterol 2013; 19(48): 9461-9471
URL	http://www.wjgnet.com/1007-9327/full/v19/i48/9461.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i48.9461

Full Article (PDF)	WJG-19-9461.pdf
Manuscript File	5368-Review.doc
Answering Reviewers	5368-Answering reviewers.pdf
Copyright License Agreement	5368-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	5368-Language certificate.pdf
Peer-review Report	5368-Peer review(s).pdf
Scientific Editor Work List	5368-Scientific editor work list.doc