Publication Name	World Journal of Gastroenterology
Manuscript ID	53686
Country	Argentina

Received	2019-12-28 03:56
Peer-Review Started	2019-12-28 03:58
To Make the First Decision
Return for Revision	2020-01-11 22:57
Revised	2020-03-27 01:07
Second Decision	2020-04-03 13:05
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2020-04-04 02:54
Articles in Press	2020-04-04 02:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-04-27 06:06
Publish the Manuscript Online	2020-04-28 08:04

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Sequencing of systemic treatment for hepatocellular carcinoma: Second line competitors
Manuscript Source	Invited Manuscript
All Author List	Federico Piñero, Marcelo Silva and Massimo Iavarone
ORCID	Author(s) ORCID Number Federico Piñero http://orcid.org/0000-0002-9528-2279 Marcelo Silva http://orcid.org/0000-0002-2287-7351 Massimo Iavarone http://orcid.org/0000-0003-3493-6504
Funding Agency and Grant Number
Corresponding Author	Federico Piñero, MD, MSc, Academic Research, Doctor, Doctor, Hepatology and Liver Transplant Unit, Hospital Universitario Austral, Av. Presidente Perón 1500, Pilar, Buenos Aires B1629HJ, Argentina. fpinerof@cas.austral.edu.ar
Key Words	Hepatocellular carcinoma; Systemic; Options; Sequencing; Advanced; Future
Core Tip	The prognosis of advanced hepatocellular carcinoma (HCC) has been improved in the last years due to new available drugs for first and second line systemic treatments. Recent improvements in HCC molecular mechanisms have led to development of effective systemic treatments including tyrosine kinase inhibitors and immunotherapy. In this review, we describe first and second line systemic treatment options for advanced HCC focusing on sequencing therapy and comparison of different second line options.
Publish Date	2020-04-28 08:04
Citation	Piñero F, Silva M, Iavarone M. Sequencing of systemic treatment for hepatocellular carcinoma: Second line competitors. World J Gastroenterol 2020; 26(16): 1888-1900
URL	https://www.wjgnet.com/1007-9327/full/v26/i16/1888.htm
DOI	https://dx.doi.org/10.3748/wjg.v26.i16.1888

Full Article (PDF)	WJG-26-1888.pdf
Full Article (Word)	WJG-26-1888.docx
Manuscript File	53686-Review.docx
Answering Reviewers	53686-Answering reviewers.pdf
Audio Core Tip	53686-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	53686-Conflict-of-interest statement.pdf
Copyright License Agreement	53686-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	53686-Language certificate.pdf
Peer-review Report	53686-Peer-review(s).pdf
Scientific Misconduct Check	53686-Scientific misconduct check.pdf
Scientific Editor Work List	53686-Scientific editor work list.pdf
CrossCheck Report	53686-CrossCheck report.pdf