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Articles Published Processes
5/26/2020 2:31:16 PM | Browse: 861 | Download: 1505
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Received |
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2020-01-12 04:00 |
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Peer-Review Started |
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2020-01-12 04:01 |
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To Make the First Decision |
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Return for Revision |
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2020-02-25 20:44 |
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Revised |
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2020-03-27 02:56 |
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Second Decision |
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2020-04-24 09:00 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-04-25 14:35 |
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Articles in Press |
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2020-04-25 14:35 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-05-11 00:10 |
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Typeset the Manuscript |
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2020-05-25 10:12 |
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Publish the Manuscript Online |
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2020-05-26 14:31 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Minireviews |
| Article Title |
DNA methylation and demethylation link the properties of mesenchymal stem cells: Regeneration and immunomodulation
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Tian-Yi Xin, Ting-Ting Yu and Rui-Li Yang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Beijing Natural Science Foundation |
7182182 |
| Young Elite Scientist Sponsorship Program by Cast |
YESS20170089 |
| National Natural Science Foundation of China |
81600865 |
| National Natural Science Foundation of China |
81970940 |
| National Science and Technology Major Project of the Ministry of Science and Technology of China |
2018ZX10302207 |
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| Corresponding Author |
Rui-Li Yang, DDS, PhD, Assistant Professor, Department of Orthodontics, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, No. 22 Zhongguancun South Avenue, Beijing 100081, China. ruiliyangabc@163.com |
| Key Words |
Mesenchymal stem cells; DNA methylation and demethylation; Multi-lineage differentiation; Regeneration; Immunomodulation; Immune disease |
| Core Tip |
Mesenchymal stem cells (MSCs) harbor the capacity to regenerate diverse tissues and can also perform key immunomodulatory functions. DNA methylation and demethylation are known to modulate stem cell maintenance and differentiation in embryonic stem cells. However, the role of DNA methylation and demethylation in MSC-based tissue regeneration and immunomodulation requires further investigation. In this review, we discuss how DNA methylation and demethylation function in multi-lineage cell differentiation and immunomodulation of MSCs based on previously published work. In addition, we discuss the implications of the role of DNA methylation and demethylation in MSCs for the treatment of metabolic or immune-related diseases. |
| Publish Date |
2020-05-26 14:31 |
| Citation |
Xin TY, Yu TT, Yang RL. DNA methylation and demethylation link the properties of mesenchymal stem cells: Regeneration and immunomodulation. World J Stem Cells 2020; 12(5): 351-358 |
| URL |
https://www.wjgnet.com/1948-0210/full/v12/i5/351.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v12.i5.351 |
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