| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Control Study |
| Article Title |
Single-nucleotide polymorphisms based genetic risk score in the prediction of pancreatic cancer risk
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Xiao-Yi Wang, Hai-Tao Chen, Rong Na, De-Ke Jiang, Xiao-Ling Lin, Feng Yang, Chen Jin, De-Liang Fu and Jian-Feng Xu |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
De-Liang Fu, MD, PhD, Doctor, Doctor, Professor, Surgical Oncologist, Department of Pancreatic Surgery, Pancreatic Disease Institute, Huashan Hospital, Fudan University, No. 12, Central Urumqi Road, Shanghai 200040, China. fudeliang@huashan.org.cn |
| Key Words |
Pancreatic cancer; Single nucleotide polymorphisms; Genetic risk score; Chinese population; Genome-wide association study; |
| Core Tip |
Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant tumor with no effective method for early diagnosis and high-risk population screening. In this pioneer study, we evaluated single nucleotide polymorphisms based genetic risk score (GRS) in the prediction of PDAC risk. Our results revealed that GRS was significantly associated with PDAC (odd ratios: 1.39, 95% confidence interval: 1.03-1.84, P = 0.031). Compared with low GRS (< 1.0), subjects with high GRS (2.0) were 99% more likely to be PDAC (odd ratios: 1.99, 95% confidence interval: 1.30-3.04, P = 0.002). Although needed further verification, our study suggested that GRS was an independent risk factor for PDAC. |
| Publish Date |
2020-06-14 13:45 |
| Citation |
Wang XY, Chen HT, Na R, Jiang DK, Lin XL, Yang F, Jin C, Fu DL, Xu JF. Single-nucleotide polymorphisms based genetic risk score in the prediction of pancreatic cancer risk. World J Gastroenterol 2020; 26(22): 3076-3086 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i22/3076.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i22.3076 |
