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Articles Published Processes
6/14/2020 1:45:26 PM | Browse: 1369 | Download: 2086
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Received |
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2019-12-30 12:41 |
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Peer-Review Started |
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2019-12-30 12:44 |
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First Decision by Editorial Office Director |
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2020-01-19 18:41 |
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Return for Revision |
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2020-01-19 18:41 |
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Revised |
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2020-05-13 15:05 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2020-05-25 10:18 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2020-05-26 02:38 |
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Articles in Press |
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2020-05-26 02:38 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-06-12 08:46 |
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Publish the Manuscript Online |
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2020-06-14 13:45 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Regenerative medicine of pancreatic islets
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Irina V Arutyunyan, Timur Kh Fatkhudinov, Andrey V Makarov, Andrey V Elchaninov and Gennady T Sukhikh |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| President Grant for Government Support of Young Russian Scientists |
075-15-2019-1120 |
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| Corresponding Author |
Timur Kh Fatkhudinov, DSc, MD, PhD, Academic Research, Laboratory of Growth and Development, Scientific Research Institute of Human Morphology, 3 Tsurupa Street, Moscow 117418, Russia, Moscow 117418, Russia. tfat@yandex.ru |
| Key Words |
Pancreas; Islets of Langerhans; β-cells; Regeneration; Replacement; Transplantation |
| Core Tip |
The review discusses the most promising strategies for regenerative medicine to stimulate the regeneration or replacement of the islet of the pancreas. The “regeneration” strategy aims to maintain a preserved population of β-cells through replication, or evoke the intrinsic adaptive mechanisms. The “replacement” strategy implies transplantation of β-cells or β-like cells obtained ex vivo from progenitors or mature somatic cells (hepatocytes or α-cells). We believe that the huge volume of experimental and clinical studies currently under way will finally allow a safe and effective solution to simple goal-restoration of the active β-cells. |
| Publish Date |
2020-06-14 13:45 |
| Citation |
Arutyunyan IV, Fatkhudinov TK, Makarov AV, Elchaninov AV, Sukhikh GT. Regenerative medicine of pancreatic islets. World J Gastroenterol 2020; 26(22): 2948-2966 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i22/2948.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i22.2948 |
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