| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
Pancreatic neuroendocrine tumors: A review of serum biomarkers, staging, and management
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Zu-Yi Ma, Yuan-Feng Gong, Hong-Kai Zhuang, Zi-Xuan Zhou, Shan-Zhou Huang, Yi-Ping Zou, Bo-Wen Huang, Zhong-Hai Sun, Chuan-Zhao Zhang, Yun-Qiang Tang and Bao-Hua Hou |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Guangzhou Health and Family Planning Technology Project |
20191A011096 |
| National Natural Science Foundation of China |
81602172 |
| Guangdong Provincial Science and Technology Plan Projects |
2016A030313769 |
| Guangzhou Science and Technology Plan of Scientifc Research Projects |
201707010323 |
|
| Corresponding Author |
Bao-Hua Hou, MD, PhD, Director, Director, Professor, Surgeon, Department of General Surgery, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, No.106 Zhongshan 2nd Rd, Yuexiu District, Guangzhou 510080, Guangdong Province, China. houbaohuahbp@163.com |
| Key Words |
Pancreatic neuroendocrine tumor; Serum biomarkers; Staging; Grading; Management; Therapy |
| Core Tip |
Pancreatic neuroendocrine tumors are a heterogeneous group of tumors with complicated treatment. There are several highlights of our manuscript. Firstly, we summarized conventional and new advances in serum biomarkers, like circulating tumor cells, multiple transcripts analysis, miRNAs profile and cytokines. Then we reviewed the changes of each guidelines of grading and staging systems and the clinical evidence behind them. Lastly surgical resection is still the only curative therapeutic option for localized pancreatic neuroendocrine tumors. Great progresses have been achieved in drug therapy and the combination with local control treatments. We summarize new advances in detail and provided potential strategies for neuroendocrine tumor associated with liver metastases management. |
| Publish Date |
2020-05-21 12:02 |
| Citation |
Ma ZY, Gong YF, Zhuang HK, Zhou ZX, Huang SZ, Zou YP, Huang BW, Sun ZH, Zhang CZ, Tang YQ, Hou BH. Pancreatic neuroendocrine tumors: A review of serum biomarkers, staging, and management. World J Gastroenterol 2020; 26(19): 2305-2322 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i19/2305.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i19.2305 |
