ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Observational Study |
Article Title |
Type I and type II Helicobacter pylori infection status and their impact on gastrin and pepsinogen level in a gastric cancer prevalent area
|
Manuscript Source |
Unsolicited Manuscript |
All Author List |
Lin Yuan, Jun-Bo Zhao, Ying-Lei Zhou, Ya-Bin Qi, Qiong-Ya Guo, Hai-Hui Zhang, Muhammad Noman Khan, Ling Lan, Chang-He Jia, Yan-Rui Zhang and Song-Ze Ding |
ORCID |
|
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
National Natural Science Foundation of China |
U1604174 |
Henan Provincial Government-Health and Family Planning Commission |
20170123 |
Henan Provincial Government-Health and Family Planning Commission Research Innovative Talents Project |
51282 |
Henan Provincial Government-Science and Technology Bureau |
142300410050 |
|
Corresponding Author |
Song-Ze Ding, MD, PhD, Chief Doctor, Professor, Department of Gastroenterology and Hepatology, People’s Hospital of Zhengzhou University, No. 7 Weiwu Road, Jinshui District, Zhengzhou 450003, Henan Province, China. dingsongze@hotmail.com |
Key Words |
Helicobacter pylori; Chronic gastric diseases; Gastrin-17; Pepsinogen; Gastric cancer; |
Core Tip |
Type I and type II Helicobacter pylori (H. pylori) infection status, and their impact on gastrin-17 and pepsinogen level in chronic gastric diseases have not been studied in this high gastric cancer risk area. Our results show that type I H. pylori infection is the major form of infection, and a very low percentage (11.6%) of gastric cancer patients are not infected by H. pylori. Both type I and type II H. pylori induce an increased gastrin-17 level, while type I H. pylori is the major strain that affects pepsinogen (PG) I, PG II level and PG I/PG II ratio in stepwise gastric disease in this geographic area. |
Publish Date |
2020-07-07 14:50 |
Citation |
Yuan L, Zhao JB, Zhou YL, Qi YB, Guo QY, Zhang HH, Khan MN, Lan L, Jia CH, Zhang YR, Ding SZ. Type I and type II Helicobacter pylori infection status and their impact on gastrin and pepsinogen level in a gastric cancer prevalent area. World J Gastroenterol 2020; 26(25): 3673-3685 |
URL |
https://www.wjgnet.com/1007-9327/full/v26/i25/3673.htm |
DOI |
https://dx.doi.org/10.3748/wjg.v26.i25.3673 |