| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Topic Highlights |
| Article Title |
Immunotherapy for colorectal cancer
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Shigeo Koido, Toshifumi Ohkusa, Sadamu Homma, Yoshihisa Namiki, Kazuki Takakura, Keisuke Saito, Zensho Ito, Hiroko Kobayashi, Mikio Kajihara, Kan Uchiyama, Seiji Arihiro, Hiroshi Arakawa, Masato Okamoto, Jianlin Gong and Hisao Tajiri |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Grants in Aid for Scientific Research (C) from the Japanese Ministry of Education, Culture, Sports, Science and Technology |
|
|
| Corresponding Author |
Shigeo Koido, MD, Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, 163-1 Kashiwashita, Kashiwa-shi, Chiba 277-8567, Japan. shigeo_koido@jikei.ac.jp
|
| Key Words |
Colorectal cancer; Cytotoxic T lymphocyte; Dendritic cell; Immunotherapy; Vaccine |
| Core Tip |
The prognosis for patients with recurrent or metastatic colorectal cancer (CRC) is extremely poor. Immunotherapy may be effective for treating CRC patients and/or preventing relapse. The immunotherapeutic approaches for CRC, including peptide vaccines, dendritic cell-based cancer vaccines, whole tumor cell vaccines, viral vector-based cancer vaccines, adoptive cell transfer therapy, antibody-based cancer immunotherapy, and cytokine therapy have been demonstrated. The blockade of multiple immune regulatory checkpoints combined with immunotherapy and/or conventional chemotherapy may be effective in treating patients with advanced CRC.
|
| Publish Date |
2013-12-18 10:00 |
| Citation |
Koido S, Ohkusa T, Homma S, Namiki Y, Takakura K, Saito K, Ito Z, Kobayashi H, Kajihara M, Uchiyama K, Arihiro S, Arakawa H, Okamoto M, Gong J, Tajiri H. Immunotherapy for colorectal cancer. World J Gastroenterol 2013; 19(46): 8531-8542 |
| URL |
http://www.wjgnet.com/1007-9327/full/v19/i46/8531.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v19.i46.8531 |
