Publication Name	World Journal of Gastroenterology
Manuscript ID	54114
Country	Thailand

Received	2020-01-27 06:12
Peer-Review Started	2020-02-03 03:37
To Make the First Decision
Return for Revision	2020-02-29 22:09
Revised	2020-03-27 08:04
Second Decision	2020-05-12 09:27
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-05-12 21:34
Articles in Press	2020-05-12 21:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-05-27 09:25
Publish the Manuscript Online	2020-05-28 13:08

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Immunology
Manuscript Type	Retrospective Study
Article Title	Decreased of BAFF-R expression and B cells maturation in patients with hepatitis B virus-related hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Apichaya Khlaiphuengsin, Natthaya Chuaypen, Pimpayao Sodsai, Supranee Buranapraditkun, Tadech Boonpiyathad, Nattiya Hirankarn and Pisit Tangkijvanich
ORCID	Author(s) ORCID Number Apichaya Khlaiphuengsin http://orcid.org/0000-0001-5797-5747 Natthaya Chuaypen http://orcid.org/0000-0002-5415-510X Pimpayao Sodsai http://orcid.org/0000-0003-0368-9416 Supranee Buranapraditkun http://orcid.org/0000-0001-9971-4318 Tadech Boonpiyathad http://orcid.org/0000-0001-8690-7647 Nattiya Hirankarn http://orcid.org/0000-0003-2224-6856 Pisit Tangkijvanich http://orcid.org/0000-0002-2926-8671
Funding Agency and Grant Number	Funding Agency Grant Number The Thailand Research Fund RTA6280004 The Grant for Chula Research Scholar CU-GRS-61-07-30-02 Second Century Fund (C2F), Chulalongkorn University Center of Excellence in Hepatitis and Liver Cancer, Faculty of Medicine, Chulalongkorn University
Corresponding Author	Pisit Tangkijvanich, MD, Doctor, Professor, Center of Excellence in Hepatitis and Liver Cancer, Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, 1873 Rama 4 Road, Pathumwan, Bangkok 10330, Thailand. pisittkvn@yahoo.com
Key Words	B cells; Hepatitis B virus; Hepatocellular carcinoma; B cell-activating factor receptor; ;
Core Tip	This study explored the expression of B cell-activating factor receptor (BAFF-R) and B cell subpopulations in patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Our data showed that BAFF-R expression was significantly lower in patient with HCC compared with non-HCC and healthy controls. In addition, the frequencies of CD27+IgD+ memory B cells, CD27+IgD- class-switched memory B cells and plasmablasts were significantly lower in the patients with HCC compared to patients without HCC. In addition, decreased BAFF-R expression was significantly correlated with tumor size and tumor stage. This study is the first report suggesting that the depletion of BAFF-R in B cells might be responsible for B cell maturation in patients with HBV-related HCC.
Publish Date	2020-05-28 13:08
Citation	Khlaiphuengsin A, Chuaypen N, Sodsai P, Buranapraditkun S, Boonpiyathad T, Hirankarn N, Tangkijvanich P. Decreased of BAFF-R expression and B cells maturation in patients with hepatitis B virus-related hepatocellular carcinoma. World J Gastroenterol 2020; 26(20): 2645-2656
URL	https://www.wjgnet.com/1007-9327/full/v26/i20/2645.htm
DOI	https://dx.doi.org/10.3748/wjg.v26.i20.2645

Full Article (PDF)	WJG-26-2645.pdf
Full Article (Word)	WJG-26-2645.docx
Manuscript File	54114-Review.docx
Answering Reviewers	54114-Answering reviewers.pdf
Audio Core Tip	54114-Audio core tip.m4a
Biostatistics Review Certificate	54114-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	54114-Conflict-of-interest statement.pdf
Copyright License Agreement	54114-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	54114-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	54114-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	54114-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	54114-Language certificate.pdf
Supplementary Material	54114-Supplementary material.pdf
Peer-review Report	54114-Peer-review(s).pdf
Scientific Misconduct Check	54114-Scientific misconduct check.pdf
Scientific Editor Work List	54114-Scientific editor work list.pdf