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Articles Published Processes
6/28/2020 10:42:01 AM | Browse: 1113 | Download: 1638
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Received |
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2020-03-04 11:38 |
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Peer-Review Started |
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2020-03-04 11:38 |
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To Make the First Decision |
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Return for Revision |
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2020-04-12 17:42 |
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Revised |
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2020-04-24 15:29 |
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Second Decision |
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2020-05-29 09:30 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-05-29 23:10 |
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Articles in Press |
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2020-05-29 23:10 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-06-04 21:56 |
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Typeset the Manuscript |
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2020-06-27 08:24 |
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Publish the Manuscript Online |
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2020-06-28 10:42 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Hepatoprotective effects of Hovenia dulcis seeds against alcoholic liver injury and related mechanisms investigated via network pharmacology
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiao Meng, Guo-Yi Tang, Cai-Ning Zhao, Qing Liu, Xiao-Yu Xu and Shi-Yu Cao |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Xiao Meng, PhD, Lecturer, Department of Nutrition, School of Public Health, Sun Yat-Sen University, No. 74 Zhongshan Road 2, Yuexiu District, Guangzhou 510080, Guangdong Province, China. mengx7@mail2.sysu.edu.cn |
| Key Words |
Hovenia dulcis; Alcoholic liver disease; Antioxidant activity; Hepatoprotection; Oxidative stress; Network pharmacology |
| Core Tip |
Although some parts of Hovenia dulcis (H. dulcis) provide health impacts, the effects and mechanisms of H. dulcis seeds on alcoholic liver disease (ALD) have not been fully elucidated. In this study, we found that H. dulcis seeds possessed strong antioxidant activity, and contained considerable phenols and flavonoids. H. dulcis seeds attenuated ALD, and improved hepatic antioxidant capacity. Furthermore, results of network pharmacology analyses indicated that kaempferol, stigmasterol and naringenin were the main bioactive compounds in H. dulcis seeds, and that modulating oxidative stress, inflammation, gut-derived products and apoptosis were involved in the mechanisms of H. dulcis seeds’ protective effects on ALD. |
| Publish Date |
2020-06-28 10:42 |
| Citation |
Meng X, Tang GY, Zhao CN, Liu Q, Xu XY, Cao SY. Hepatoprotective effects of Hovenia dulcis seeds against alcoholic liver injury and related mechanisms investigated via network pharmacology. World J Gastroenterol 2020; 26(24): 3432-3446 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i24/3432.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i24.3432 |
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