Publication Name	World Journal of Gastroenterology
Manuscript ID	5423
Country	China

Received	2013-09-06 14:28
Peer-Review Started	2013-09-06 16:02
To Make the First Decision	2013-09-27 16:43
Return for Revision	2013-09-29 10:24
Revised	2013-10-17 13:40
Second Decision	2013-11-01 16:59
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-11-03 11:42
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-11-10 13:08
Typeset the Manuscript	2013-12-03 08:39
Publish the Manuscript Online	2013-12-18 10:39

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Biochemistry & Molecular Biology
Manuscript Type	Topic Highlights
Article Title	Nickel trafficking system responsible for urease maturation in Helicobacter pylori
Manuscript Source	Invited Manuscript
All Author List	Rui-Guang Ge, Dong-Xian Wang, Ming-Cong Hao and Xue-Song Sun
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 20801061 National Natural Science Foundation of China 31000373 National Natural Science Foundation of China 21371182 Fundamental Research Funds for the Central Universities 10lgpy19 Fundamental Research Funds for the Central Universities 21611201 Pearl River Rising Star of Science and Technology of Guangzhou City, China 2011J2200079 Pearl River Rising Star of Science and Technology of Guangzhou City, China 2011J2200003
Corresponding Author	Rui-Guang Ge, PhD, Associate Professor, Key Laboratory of Gene Engineering of the Ministry of Education and State Key Laboratory of Biocontrol, College of Life Sciences, Sun Yat-sen University, No 135, Xingang West, Guangzhou 510275, Guangdong Province, China. gerg@mail.sysu.edu.cn
Key Words	Urease; Histidine-rich protein; NikR; NixA; Helicobacter pylori
Core Tip	Helicobacter pylori (H. pylori) is responsible for various gastric diseases. The nickel containing urease and hydrogenase are essential for the successful infections of H. pylori in the stomach. Nickel is an essential cofactor for urease and hydrogenase. In this review we discussed the various regulatory, uptake, chaperone and accessory proteins involved in the maturation of urease, especially the proteins NikR, NixA, HypAB, UreEFGH, HspA, Hpn and Hpnl. The work will deepen our understanding of how this pathogenic bacterium adapts to severe habitant environments in the host.
Publish Date	2013-12-18 10:39
Citation	Ge RG, Wang DX, Hao MC, Sun XS. Nickel trafficking system responsible for urease maturation in Helicobacter pylori. World J Gastroenterol 2013; 19(45): 8211-8218
URL	http://www.wjgnet.com/1007-9327/full/v19/i45/8211.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i45.8211

Full Article (PDF)	WJG-19-8211.pdf
Manuscript File	5423-Review.doc
Answering Reviewers	5423-Answering Reviewers.pdf
Copyright License Agreement	5423-Copyright Assignment.pdf
Peer-review Report	5423-Peer Review(s).pdf
Scientific Editor Work List	5423-Scientific editor work list.doc