Publication Name	World Journal of Gastroenterology
Manuscript ID	5424
Country	China

Received	2013-09-06 14:35
Peer-Review Started	2013-09-06 16:09
To Make the First Decision	2013-09-16 20:22
Return for Revision	2013-09-18 16:20
Revised	2013-09-27 23:07
Second Decision	2013-10-14 09:53
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-10-14 13:17
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-12-13 15:55
Publish the Manuscript Online	2014-01-20 16:41

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Meta-Analysis
Article Title	Efficacy of mosapride plus proton pump inhibitors for treatment of gastroesophageal reflux disease: A systematic review
Manuscript Source	Invited Manuscript
All Author List	Qing Liu, Chen-Chen Feng, Er-Man Wang, Xiu-Juan Yan and Sheng-Liang Chen
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 31171106 National Natural Science Foundation of China 81070302 National Natural Science Foundation of China 81270463
Corresponding Author	Sheng-Liang Chen, MD, Professor, Department of Gastroenterology, Ren Ji Hospital, School of Medicine, Shanghai Institute of Digestive Disease, Shanghai Jiao Tong University, 145 Middle Shandong Road, Shanghai 200001, China. slchenmd@hotmail.com
Key Words	Mosapride; Proton pump inhibitor; Gastroesophageal reflux disease; Systematic review; Combined therapy
Core Tip	Prokinetic agents have been widely used to relieve the gastroesophageal reflux disease (GERD) symptoms, and mosapride is a selective 5-HT4 receptor agonist that can be safely used. We conducted a systematic review and meta-analysis to assess the potential benefits of the addition of mosapride to proton pump inhibitors (PPIs) in the treatment of GERD. Based on this research, mosapride combined therapy seems to be not more effective than PPI alone as first-line therapy. Whether it is effective in PPI-resistant patients needs to be determined.
Publish Date	2014-01-20 16:41
Citation	Liu Q, Feng CC, Wang EM, Yan XJ, Chen SL. Efficacy of mosapride plus proton pump inhibitors for treatment of gastroesophageal reflux disease: A systematic review. World J Gastroenterol 2013; 19(47): 9111-9118
URL	http://www.wjgnet.com/1007-9327/full/v19/i47/9111.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i47.9111

Full Article (PDF)	WJG-19-9111.pdf
Manuscript File	5424-Review.doc
Answering Reviewers	5424-Answering Reviewers.pdf
Copyright License Agreement	5424-Copyright Assignment.pdf
Non-Native Speakers of English Editing Certificate	5424-Language Certificate.pdf
Peer-review Report	5424-Peer Review(s).pdf
Scientific Editor Work List	5424-Scientific editor work list.doc