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Articles Published Processes
8/28/2014 3:52:00 PM | Browse: 940 | Download: 903
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Received |
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2013-09-07 20:36 |
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Peer-Review Started |
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2013-09-09 15:34 |
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To Make the First Decision |
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2013-10-14 21:00 |
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Return for Revision |
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2013-10-15 11:36 |
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Revised |
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2013-10-22 19:04 |
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Second Decision |
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2014-01-05 14:54 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-01-05 15:23 |
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Articles in Press |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2014-04-21 10:26 |
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Publish the Manuscript Online |
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2014-05-07 10:10 |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Autobiography |
| Article Title |
Caecal pH is a biomarker of excessive colonic fermentation
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Adam D Farmer, Sahar D Mohammed, George E Dukes, S Mark Scott and Anthony R Hobson |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| SmartPill Corporation |
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| Corresponding Author |
Anthony R Hobson, PhD, Consultant Clinical Scientist, Functional Gut Clinic, 22 Upper Wimpole Street, London W1G 6NB, United Kingdom. anthonyhobson@hotmail.com |
| Key Words |
Caecal pH; Caecoparesis; Bloating; Colonic microbiota; Fermentation |
| Core Tip |
Colonic bacterial fermentation has been implicated in the pathogenesis of irritable bowel syndrome. Hitherto, the measurement of fermentation in vivo in humans has been invasive and technically challenging. A major by product of colonic bacterial fermentation are short chain fatty acids. These short chain fatty acids act to reduce colonic pH. Herein, we demonstrate that the measurement of caecal ph using the wireless motility capsule provides a quantifiable biomarker of fermentation potentially identifying those patients with irritable bowel syndrome that may preferentially benefit from antibiotic or dietary interventions. |
| Publish Date |
2014-05-07 10:10 |
| Citation |
Farmer AD, Mohammed SD, Dukes GE, Scott SM, Hobson AR. Caecal pH is a biomarker of excessive colonic fermentation. World J Gastroenterol 2014; 20(17): 5000-5007 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i17/5000.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i17.5000 |
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