Publication Name	World Journal of Gastroenterology
Manuscript ID	5434
Country	Brazil

Received	2013-09-07 20:53
Peer-Review Started	2013-09-09 15:56
To Make the First Decision	2013-09-27 16:39
Return for Revision	2013-09-29 09:21
Revised	2013-10-17 02:32
Second Decision	2013-11-29 11:11
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-11-30 01:24
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-03-11 15:44
Publish the Manuscript Online	2014-03-27 12:04

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Thiopurine-methyltransferase variants in inflammatory bowel disease: Prevalence and toxicity in Brazilian patients
Manuscript Source	Invited Manuscript
All Author List	Ana Teresa P Carvalho, Barbara C Esberard, Renata S B Fróes, Davy C M Rapozo, Ana B Grinman, Tatiana A Simão, Juliana C V C Santos, Antonio José V Carneiro, Luis Felipe Ribeiro-Pinto and Heitor S P de Souza
Funding Agency and Grant Number	Funding Agency Grant Number Brazilian research agencies CNPq and FAPERJ for financial support
Corresponding Author	Heitor S P de Souza, MD, Serviço de Gastroenterologia, Departamento de Clínica Médica, Universidade Federal do Rio de Janeiro. Rua Prof. Rodolpho Paulo Rocco, 255, Ilha do Fundão, Rio de Janeiro, RJ 21941-913, Brazil. heitor.souza@gmail.com
Key Words	Inflammatory bowel disease; Thiopurine-methyl-transferase; Azathioprine; Drug toxicity; Pancreatitis
Core Tip	Although commonly used to treat patients with inflammatory bowel disease, the potentially severe side effects of azathioprine remain a concern. To determine a patient’s predisposition to azathioprine toxicity, the thiopurine-methyl-transferase genotype must be determined prior to azathioprine administration.
Publish Date	2014-03-27 12:04
Citation	Carvalho ATP, Esberard BC, Fróes RSB, Rapozo DCM, Grinman AB, Sim?o TA, Santos JCVC, Carneiro AJV, Ribeiro-Pinto LF, de Souza HSP. Thiopurine-methyltransferase variants in inflammatory bowel disease: Prevalence and toxicity in Brazilian patients. World J Gastroenterol 2014; 20(12): 3327-3334
URL	http://www.wjgnet.com/1007-9327/full/v20/i12/3327.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i12.3327

Full Article (PDF)	WJG-20-3327.pdf
Full Article (Word)	WJG-20-3327.doc
Manuscript File	5434-Review.doc
Answering Reviewers	5434-Answering Reviewers.pdf
Copyright License Agreement	5434-Copyright Assignment.pdf
Non-Native Speakers of English Editing Certificate	5434-Language Certificate.pdf
Peer-review Report	5434-Peer Review(s).pdf
Scientific Editor Work List	5434-Scientific editor work list.doc