Publication Name	World Journal of Clinical Oncology
Manuscript ID	5435
Country	China

Received	2013-09-07 20:57
Peer-Review Started	2013-09-09 16:05
To Make the First Decision	2013-10-14 14:08
Return for Revision	2013-10-14 18:09
Revised	2013-11-02 00:46
Second Decision	2013-11-15 18:57
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-11-16 00:53
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-12-01 11:50
Typeset the Manuscript	2014-01-20 09:57
Publish the Manuscript Online	2014-02-10 09:34

ISSN	2218-4333 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Review
Article Title	Temozolomide for treatment of brain metastases: A review of 21 clinical trials
Manuscript Source	Invited Manuscript
All Author List	Wei Zhu, Li Zhou, Jia-Qi Qian, Tian-Zhu Qiu, Yong-Qian Shu and Ping Liu
Funding Agency and Grant Number
Corresponding Author	Ping Liu, MD, PhD, Chief Physician, Professor, Department of Oncology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, China. belliwether@163.com
Key Words	Temozolomide; Solid tumours; Brain metastases; Clinical trials; Clinical outcomes
Core Tip	Temozolomide has been used in glioblastoma multiforme as well as melanoma. Recently, studies showed that it might be also effective in patients with brain metastases from various malignancies. In this study, we carried out a review of 21 published clinical trials to determine whether temozolomide would benefit patients with brain metastases from solid tumours. As a result, a modest therapeutic effect was observed when temozolomide was used as a single agent, however, the combination of temozolomide with whole-brain radiotherapy and/or other anticancer drugs exhibited encouraging activity. This study for the first time provided a systematic evaluation of temozolomide in the treatment of brain metastases.
Publish Date	2014-02-10 09:34
Citation	Zhu W, Zhou L, Qian JQ, Qiu TZ, Shu YQ, Liu P. Temozolomide for treatment of brain metastases: A review of 21 clinical trials. World J Clin Oncol 2013; 5(1): 19-27
URL	http://www.wjgnet.com/2218-4333/full/v5/i1/19.htm
DOI	http://dx.doi.org/10.5306/wjco.v5.i1.19

Full Article (PDF)	wjco-5-1.pdf
Full Article (Word)	wjco-5-1.doc
Manuscript File	5435-Review.doc
Answering Reviewers	5435-Answering reviewers.pdf
Copyright License Agreement	5435-Copyright assignment.pdf
Peer-review Report	5435-Peer review(s).pdf
Scientific Editor Work List	5435-Scientific editor work list.doc