Publication Name	World Journal of Gastroenterology
Manuscript ID	5438
Country	China

Received	2013-09-09 08:29
Peer-Review Started	2013-09-09 16:20
To Make the First Decision	2013-10-14 20:59
Return for Revision	2013-10-15 11:34
Revised	2013-11-13 01:21
Second Decision	2013-11-29 11:18
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-11-30 01:25
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-12-12 10:38
Typeset the Manuscript	2014-02-18 09:10
Publish the Manuscript Online	2014-03-12 11:24

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Sophocarpine attenuates liver fibrosis by inhibiting the TLR4 signaling pathway in rats
Manuscript Source	Invited Manuscript
All Author List	Hui Qian, Jian Shi, Ting-Ting Fan, Jiao Lv, Si-Wen Chen, Chun-Yan Song, Zhi-Wu Zheng, Wei-Fen Xie and Yue-Xiang Chen
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 30971343 National Natural Science Foundation of China 81270486 National Natural Science Foundation of China 81000167 National Natural Science Foundation of China 81370009
Corresponding Author	Yue-Xiang Chen, Professor, Department of Gastroenterology, Shanghai Changzheng Hospital, Second Military Medical University, 415 Fengyang Rd, Shanghai 200003, China. yuexchen1807@163.com
Key Words	Liver fibrosis; Sophocarpine; Toll-like receptor 4; Hepatic stellate cells; Cytokines
Core Tip	Sophocarpine significantly ameliorated liver function and hepatic fibrosis in both the dimethylnitrosamine and bile duct ligation models. In addition, sophocarpine inhibited the activation and proliferation of hepatic stellate cells in vitro, which contributed to the anti-fibrotic effect of sophocarpine in vivo. Toll-like receptor 4 signaling was blocked by sophocarpine in vivo and in vitro, accompanied by a reduction in pro-inflammatory and fibrotic cytokines, as well a decrease in the expression of Cyclin D1 and proliferating cell nuclear antigen.
Publish Date	2014-03-12 11:24
Citation	Qian H, Shi J, Fan TT, Lv J, Chen SW, Song CY, Zheng ZW, Xie WF, Chen YX. Sophocarpine attenuates liver fibrosis by inhibiting the TLR4 signaling pathway in rats. World J Gastroenterol 2014; 20(7): 1822-1832
URL	http://www.wjgnet.com/1007-9327/full/v20/i7/1822.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i7.1822

Full Article (PDF)	WJG-20-1822.pdf
Full Article (Word)	WJG-20-1822.doc
Manuscript File	5438-Review.doc
Answering Reviewers	5438-Answering reviewers.pdf
Copyright License Agreement	5438-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	5438-Language certificate.PDF
Peer-review Report	5438-Peer review(s).pdf
Scientific Editor Work List	5438-Scientific editor work list.doc