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Articles Published Processes
9/2/2014 5:02:00 PM | Browse: 1058 | Download: 1174
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Received |
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2013-09-09 08:29 |
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Peer-Review Started |
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2013-09-09 16:20 |
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To Make the First Decision |
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2013-10-14 20:59 |
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Return for Revision |
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2013-10-15 11:34 |
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Revised |
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2013-11-13 01:21 |
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Second Decision |
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2013-11-29 11:18 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2013-11-30 01:25 |
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Articles in Press |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2013-12-12 10:38 |
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Typeset the Manuscript |
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2014-02-18 09:10 |
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Publish the Manuscript Online |
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2014-03-12 11:24 |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Autobiography |
Article Title |
Sophocarpine attenuates liver fibrosis by inhibiting the TLR4 signaling pathway in rats
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Manuscript Source |
Invited Manuscript |
All Author List |
Hui Qian, Jian Shi, Ting-Ting Fan, Jiao Lv, Si-Wen Chen, Chun-Yan Song, Zhi-Wu Zheng, Wei-Fen Xie and Yue-Xiang Chen |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
National Natural Science Foundation of China |
30971343 |
National Natural Science Foundation of China |
81270486 |
National Natural Science Foundation of China |
81000167 |
National Natural Science Foundation of China |
81370009 |
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Corresponding Author |
Yue-Xiang Chen, Professor, Department of Gastroenterology, Shanghai Changzheng Hospital, Second Military Medical University, 415 Fengyang Rd, Shanghai 200003, China. yuexchen1807@163.com |
Key Words |
Liver fibrosis; Sophocarpine; Toll-like receptor 4; Hepatic stellate cells; Cytokines |
Core Tip |
Sophocarpine significantly ameliorated liver function and hepatic fibrosis in both the dimethylnitrosamine and bile duct ligation models. In addition, sophocarpine inhibited the activation and proliferation of hepatic stellate cells in vitro, which contributed to the anti-fibrotic effect of sophocarpine in vivo. Toll-like receptor 4 signaling was blocked by sophocarpine in vivo and in vitro, accompanied by a reduction in pro-inflammatory and fibrotic cytokines, as well a decrease in the expression of Cyclin D1 and proliferating cell nuclear antigen. |
Publish Date |
2014-03-12 11:24 |
Citation |
Qian H, Shi J, Fan TT, Lv J, Chen SW, Song CY, Zheng ZW, Xie WF, Chen YX. Sophocarpine attenuates liver fibrosis by inhibiting the TLR4 signaling pathway in rats. World J Gastroenterol 2014; 20(7): 1822-1832 |
URL |
http://www.wjgnet.com/1007-9327/full/v20/i7/1822.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v20.i7.1822 |
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