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5/27/2020 1:47:07 PM | Browse: 716 | Download: 1184
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Received |
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2020-01-25 21:47 |
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Peer-Review Started |
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2020-01-25 21:48 |
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To Make the First Decision |
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Return for Revision |
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2020-04-19 21:44 |
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Revised |
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2020-05-09 18:54 |
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Second Decision |
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2020-05-12 08:31 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-05-13 06:34 |
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Articles in Press |
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2020-05-13 06:34 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-05-18 08:02 |
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Publish the Manuscript Online |
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2020-05-27 13:47 |
| ISSN |
2219-2824 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Editorial |
| Article Title |
PICOT promotes T lymphocyte proliferation by down-regulating cyclin D2 expression
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Pinakin Pandya and Noah Isakov |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| USA-Israel Binational Science Foundation |
2013034 |
| Israel Science Foundation administered by the Israel Academy of Science |
1235/17 |
| Jacki and Bruce Barron Cancer Research Scholars’ Program, City of Hope and the Israel Cancer Research Fund |
87735611 |
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| Corresponding Author |
Noah Isakov, PhD, Professor, The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences and the Cancer Research Center, Ben Gurion University of the Negev, P.O.B. 653, Beer Sheva 84105, Israel. noah@bgu.ac.il |
| Key Words |
Protein kinase C-interacting cousin of thioredoxin; Glutaredoxin 3; Cyclin D2; Histone methylation; T lymphocyte; Histone 3 lysine 27 trimethylation |
| Core Tip |
Protein kinase C-interacting cousin of thioredoxin (PICOT) is a cell growth-regulating protein that interacts with embryonic ectoderm development, a core component of the polycomb repressive complex 2. PICOT is able to alter the extent of the tri-methylation of histone 3 lysine 27 at the promoter region of the polycomb repressive complex 2 target gene, CCND2, which encodes the cell cycle-regulating protein, cyclin D2. High expression levels of PICOT correlates with low expression levels of CCND2 and poor survival of a large number of human cancer patients. The results suggest that a high PICOT/CCND2 expression level ratio might serve as a predictor of patient survival in selected types of human cancer. |
| Publish Date |
2020-05-27 13:47 |
| Citation |
Pandya P, Isakov N. PICOT promotes T lymphocyte proliferation by down-regulating cyclin D2 expression. World J Immunol 2020; 10(1): 1-12 |
| URL |
https://www.wjgnet.com/2219-2824/full/v10/i1/1.htm |
| DOI |
https://dx.doi.org/10.5411/wji.v10.i1.1 |
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