Publication Name	World Journal of Gastroenterology
Manuscript ID	54419
Country	Australia

Received	2020-01-30 05:33
Peer-Review Started	2020-01-30 05:33
To Make the First Decision
Return for Revision	2020-03-15 04:14
Revised	2020-03-18 03:59
Second Decision	2020-05-20 10:55
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2020-05-21 03:00
Articles in Press	2020-05-21 03:00
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-06-05 01:27
Publish the Manuscript Online	2020-06-06 14:43

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Importance of investigating high-risk human papillomavirus in lymph node metastasis of esophageal adenocarcinoma
Manuscript Source	Invited Manuscript
All Author List	Preeti Sharma, Shweta Dutta Gautam and Shanmugarajah Rajendra
ORCID	Author(s) ORCID Number Preeti Sharma http://orcid.org/0000-0001-8969-0076 Shweta Dutta Gautam http://orcid.org/0000-0002-0825-1889 Shanmugarajah Rajendra http://orcid.org/0000-0002-8893-4638
Funding Agency and Grant Number
Corresponding Author	Shanmugarajah Rajendra, FRACP, FRCP, FRCPE, MBChB, MD, MSc, Director, Director, Doctor, Doctor, Professor, Gastro-Intestinal Viral Oncology Group, Ingham Institute for Applied Medical Research, 1 Campbell St, Liverpool 2170, NSW, Australia. shan.rajendra@health.nsw.gov.au
Key Words	Esophageal cancer; Esophageal adenocarcinoma; Metastasis; Lymph nodes; Human papillomavirus;
Core Tip	Esophageal adenocarcinoma (EAC) is one of the fastest growing cancers in the western world. EAC has been associated with high-risk human papillomavirus and has been shown to grant a positive prognosis in EAC. In some human papillomavirus (HPV) driven malignancies (e.g. cervical and head and neck tumors), associated lymph nodes with a high viral load suggest metastatic lymph node involvement. Therefore, HPV is a potential marker of micro-metastases. This review highlights the importance of investigating HPV in lymph node metastasis of EAC based on data derived from other HPV driven malignancies.
Publish Date	2020-06-06 14:43
Citation	Sharma P, Gautam SD, Rajendra S. Importance of investigating high-risk human papillomavirus in lymph node metastasis of esophageal adenocarcinoma. World J Gastroenterol 2020; 26(21): 2729-2739
URL	https://www.wjgnet.com/1007-9327/full/v26/i21/2729.htm
DOI	https://dx.doi.org/10.3748/wjg.v26.i21.2729

Full Article (PDF)	WJG-26-2729.pdf
Full Article (Word)	WJG-26-2729.docx
Manuscript File	54419-Review.docx
Answering Reviewers	54419-Answering reviewers.pdf
Audio Core Tip	54419-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	54419-Conflict-of-interest statement.pdf
Copyright License Agreement	54419-Copyright license agreement.pdf
Supplementary Material	54419-Supplementary material.pdf
Peer-review Report	54419-Peer-review(s).pdf
Scientific Misconduct Check	54419-Scientific misconduct check.pdf
Scientific Editor Work List	54419-Scientific editor work list.pdf
CrossCheck Report	54419-CrossCheck report.pdf