Publication Name	World Journal of Nephrology
Manuscript ID	5445
Country

Received	2013-09-09 10:26
Peer-Review Started	2013-09-09 16:56
To Make the First Decision	2013-09-17 09:28
Return for Revision	2013-09-17 12:03
Revised	2013-09-24 06:14
Second Decision	2013-10-19 14:51
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-10-20 08:32
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-11-01 16:00
Publish the Manuscript Online	2013-11-04 12:41

ISSN	2220-6124 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Urology & Nephrology
Manuscript Type	Review
Article Title	Primary focal and segmental glomerulosclerosis and soluble factor urokinase-type plasminogen activator receptor
Manuscript Source
All Author List	Hernán Trimarchi
Funding Agency and Grant Number
Corresponding Author	Hernán Trimarchi, MD, Servicio de Nefrología, Hospital Británico de Buenos Aires, Perdriel 74, Buenos Aires 1280, Argentina. htrimarchi@hotmail.com
Key Words	Primary acquired focal and segmental glomerulosclerosis; Soluble factor urokinase type plasminogen activator receptor; Proteinuria; Podocyte; Plasmin
Core Tip	Primary acquired focal and segmental glomerulosclerosis is a frequent cause of nephrotic syndrome with no specific treatment. New discoveries in its pathophysiolohy have revealed that a podocyte permeability factor named soluble urokinase plasminogen activator receptor (suPAR) may be involved in the development of proteinuria and edema formation. This effect is supposed to be achieved by its interaction with podocyte integrins and subsequent cell contraction. Moreover, suPAR also activates water and sodium retention in this disease. Interestingly, plasmin mediates both effects. Amiloride is postulated to interfere with suPAR proteinuric actions.
Publish Date	2013-11-04 12:41
Citation	Trimarchi H. Primary focal and segmental glomerulosclerosis and soluble factor urokinase-type plasminogen activator receptor. World J Nephrol 2013; 2(4): 103-110
URL	http://www.wjgnet.com/2220-6124/full/v2/i4/103.htm
DOI	http://dx.doi.org/10.5527/wjn.v2.i4.103

Full Article (PDF)	WJN-2-103.pdf
Manuscript File	5445-Review.doc
Answering Reviewers	5445-Answering Reviewers.pdf
Copyright License Agreement	5445-Copyright Assignment.pdf
Non-Native Speakers of English Editing Certificate	5445-Language Certificate.jpg
Peer-review Report	5445-Peer Review(s).pdf
Scientific Editor Work List	5445-Scientific editor work list.doc