Publication Name	World Journal of Gastroenterology
Manuscript ID	54470
Country	Poland

Received	2020-01-31 13:51
Peer-Review Started	2020-01-31 13:51
To Make the First Decision
Return for Revision	2020-04-09 16:41
Revised	2020-05-19 14:30
Second Decision	2020-05-22 08:18
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2020-05-23 01:01
Articles in Press	2020-05-23 01:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-06-18 13:20
Publish the Manuscript Online	2020-06-21 14:15

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Biochemistry & Molecular Biology
Manuscript Type	Review
Article Title	Potential of the ellagic acid-derived gut microbiota metabolite – Urolithin A in gastrointestinal protection
Manuscript Source	Invited Manuscript
All Author List	Małgorzata Kujawska and Jadwiga Jodynis-Liebert
ORCID	Author(s) ORCID Number Małgorzata Kujawska http://orcid.org/0000-0002-5306-9904 Jadwiga Jodynis-Liebert http://orcid.org/0000-0002-5008-4877
Funding Agency and Grant Number	Funding Agency Grant Number National Science Centre 2017/26/D/NZ7/00748
Corresponding Author	Małgorzata Kujawska, MSc, PhD, Adjunct Professor, Associate Professor, Department of Toxicology, Poznan University of Medical Sciences, Dojazd 30, Poznan 60631, Poland. kujawska@ump.edu.pl
Key Words	Urolithin A; Colonic metabolite; Gut microbiota; Colorectal cancer; Inflammatory bowel diseases; Hepatocellular carcinoma
Core Tip	Urolithin A (UA) - an ellagitannin metabolite generated by the intestinal bacteria at physiologically relevant micromolar concentrations, offers gastrointestinal (GI) protection. The health benefit is principally related to anticancer and anti-inflammatory effects. UA can regulate multiple tumor and inflammatory signaling pathways and enzyme activities, including those involved in carcinogen biotransformation and antioxidant defense. The presented herein data support the potential of both pure compound and in vivo generated UA in treatment interventions against GI ailments.
Publish Date	2020-06-21 14:15
Citation	Kujawska M, Jodynis-Liebert J. Potential of the ellagic acid-derived gut microbiota metabolite – Urolithin A in gastrointestinal protection. World J Gastroenterol 2020; 26(23): 3170-3181
URL	https://www.wjgnet.com/1007-9327/full/v26/i23/3170.htm
DOI	https://dx.doi.org/10.3748/wjg.v26.i23.3170

Full Article (PDF)	WJG-26-3170.pdf
Full Article (Word)	WJG-26-3170.docx
Manuscript File	54470-Review.docx
Answering Reviewers	54470-Answering reviewers.pdf
Audio Core Tip	54470-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	54470-Conflict-of-interest statement.pdf
Copyright License Agreement	54470-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	54470-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	54470-Language certificate.pdf
Peer-review Report	54470-Peer-review(s).pdf
Scientific Misconduct Check	54470-Scientific misconduct check.pdf
Scientific Editor Work List	54470-Scientific editor work list.pdf
CrossCheck Report	54470-CrossCheck report.pdf