Publication Name	World Journal of Cardiology
Manuscript ID	54472
Country	United States

Received	2020-01-31 14:20
Peer-Review Started	2020-01-31 14:20
To Make the First Decision
Return for Revision	2020-04-29 18:48
Revised	2020-06-02 18:14
Second Decision	2020-07-14 03:34
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2020-07-19 21:50
Articles in Press	2020-07-19 21:50
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-08-17 04:00
Publish the Manuscript Online	2020-08-18 02:09

ISSN	1949-8462 (online)
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Category	Genetics & Heredity
Manuscript Type	Opinion Review
Article Title	Classic Ehlers-Danlos syndrome and cardiac transplantation - Is there a connection?
Manuscript Source	Unsolicited Manuscript
All Author List	Merlin G Butler
ORCID	Author(s) ORCID Number Merlin G Butler http://orcid.org/0000-0002-2911-0524
Funding Agency and Grant Number	Funding Agency Grant Number the National Institute of Child Health and Human Development HD02528
Corresponding Author	Merlin G Butler, MD, PhD, Professor, Department of Psychiatry and Behavioral Sciences, University of Kansas Medical Center, 3901 Rainbow Boulevard, MS 4015, Kansas City, KS 66160, United States. mbutler4@kumc.edu
Key Words	Ehlers-Danlos syndrome; Next-generation sequencing; Surgical complications; Beighton hypermobility scale; Cardiac failure and transplantation;
Core Tip	Ehlers-Danlos syndrome (EDS) consists of a group of connective tissue disorders involving both autosomal dominant and recessive inheritance patterns often involving collagen genes with variants readily detectable using disease-specific gene panels with next-generation sequencing. A 55 year-old male is reported with features of a connective tissue disorder. He had a heart transplant at 43 years of age. He was found to have a COL5A1 gene variant (c:605T7A; p.I1e102Asn) causing classic EDS. He is brought to medical attention for consideration of a genetic cause of cardiac failure including EDS in other patients and complications of surgery which may occur.
Publish Date	2020-08-18 02:09
Citation	Butler MG. Classic Ehlers-Danlos syndrome and cardiac transplantation - Is there a connection? World J Cardiol 2020; 12(8): 368-372
URL	https://www.wjgnet.com/1949-8462/full/v12/i8/368.htm
DOI	https://dx.doi.org/10.4330/wjc.v12.i8.368

Full Article (PDF)	WJC-12-368.pdf
Full Article (Word)	WJC-12-368.docx
Manuscript File	54472-Review.docx
Answering Reviewers	54472-Answering reviewers.pdf
Audio Core Tip	54472-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	54472-Conflict-of-interest statement.pdf
Copyright License Agreement	54472-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	54472-Grant application form(s).pdf
Peer-review Report	54472-Peer-review(s).pdf
Scientific Misconduct Check	54472-Scientific misconduct check.pdf
Scientific Editor Work List	54472-Scientific editor work list.pdf
CrossCheck Report	54472-CrossCheck report.pdf