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Articles Published Processes
7/28/2020 2:46:56 PM | Browse: 719 | Download: 1464
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Received |
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2020-02-03 23:49 |
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Peer-Review Started |
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2020-02-03 23:49 |
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To Make the First Decision |
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Return for Revision |
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2020-02-27 03:16 |
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Revised |
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2020-05-24 22:06 |
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Second Decision |
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2020-06-17 09:16 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-06-17 20:53 |
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Articles in Press |
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2020-06-17 20:53 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-07-07 03:30 |
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Typeset the Manuscript |
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2020-07-28 07:31 |
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Publish the Manuscript Online |
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2020-07-28 14:46 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Differential regulation of JAK/STAT-signaling in patients with ulcerative colitis and Crohn’s disease
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Friederike Cordes, Dirk Foell, John Nik Ding, Georg Varga and Dominik Bettenworth |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Friederike Cordes, MD, Doctor, Doctor, Department of Medicine B for Gastroenterology and Hepatology, University Hospital Münster, Albert-Schweitzer-Campus 1, Münster D-48149, Germany. annafriederike.cordes@ukmuenster.de |
| Key Words |
Janus kinase; Signal transducer and activator of transcription; JAK/STAT pathway; Inflammatory bowel disease; Ulcerative colitis; Crohn’s disease; JAK/STAT inhibition; Tofacitinib |
| Core Tip |
The pan-Janus kinase (JAK)-inhibitor tofacitinib is efficacious in patients with active ulcerative colitis (UC) but not Crohn’s disease (CD), which hints at different contribution of JAK-signaling in both entities. In this review available data on differential JAK/signal transducer and activator of transcription (STAT)-signaling in UC and CD were analyzed. Literature review identified differential cell-subset specific JAK/STAT-signaling including increased T-cell-associated STAT1 signaling in CD and STAT6 signaling in UC, while in myeloid cells inflammatory STAT1 was increased in UC compared with CD indicating a less inflammatory role of myeloid cells in CD. Development of JAK/STAT-inhibitors with specific targeting of associated inflammatory pathways might further improve efficacy and safety profiles of this drug class. |
| Publish Date |
2020-07-28 14:46 |
| Citation |
Cordes F, Foell D, Ding JN, Varga G, Bettenworth D. Differential regulation of JAK/STAT-signaling in patients with ulcerative colitis and Crohn’s disease. World J Gastroenterol 2020; 26(28): 4055-4075 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i28/4055.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i28.4055 |
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