Publication Name	World Journal of Gastroenterology
Manuscript ID	5451
Country	China

Received	2013-09-09 10:52
Peer-Review Started	2013-09-09 17:32
To Make the First Decision	2013-09-27 16:38
Return for Revision	2013-09-27 17:49
Revised	2013-11-01 16:39
Second Decision	2013-11-18 21:05
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-11-19 12:23
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-12-01 11:53
Typeset the Manuscript	2014-02-17 16:40
Publish the Manuscript Online	2014-02-26 11:18

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Impaired balance of T helper 17/T regulatory cells in carbon tetrachloride-induced liver fibrosis in mice
Manuscript Source	Invited Manuscript
All Author List	Xiao-Fei Sun, Lei Gu, Wen-Sheng Deng and Qing Xu
Funding Agency and Grant Number	Funding Agency Grant Number Scientific Research Innovation Project of Shanghai Education Committee, China 13yz040
Corresponding Author	Qing Xu, PhD, Department of General Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, No. 160, Pujian Road, Shanghai 200127, China. surgeonxq@hotmail.com
Key Words	T helper 17 cell; Treg cell; Carbon tetrachloride; Hepatic fibrosis; Hepatic stellate cell
Core Tip	It has been reported that T helper (Th) 17/T regulatory (Treg) cell imbalance is closely related to many autoimmune diseases. The role of Th17/Treg imbalance in liver fibrosis has seldom been reported. Our study focused on the change in Th17/Treg balance in a liver fibrosis model in mice, and explored the possible mechanism through which the development of fibrosis is regulated. The frequency of Th17 cells increased, while the frequency of Treg cells decreased in liver fibrosis. These changes promote the occurrence of liver fibrosis via hepatic stellate cell activation.
Publish Date	2014-02-26 11:18
Citation	Sun XF, Gu L, Deng WS, Xu Q. Impaired balance of T helper 17/T regulatory cells in carbon tetrachloride-induced liver fibrosis in mice. World J Gastroenterol 2014; 20(8): 2062-2070
URL	http://www.wjgnet.com/1007-9327/full/v20/i8/2062.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i8.2062

Full Article (PDF)	WJG-20-2062.pdf
Full Article (Word)	WJG-20-2062.doc
Manuscript File	5451-Review.doc
Answering Reviewers	5451-Answering reviewers.pdf
Copyright License Agreement	5451-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	5451-Language certificate.PDF
Peer-review Report	5451-Peer review(s).pdf
Scientific Editor Work List	5451-Scientific editor work list.doc