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Articles Published Processes
7/14/2020 6:33:18 AM | Browse: 676 | Download: 1123
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Received |
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2020-02-17 18:01 |
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Peer-Review Started |
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2020-02-17 18:03 |
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To Make the First Decision |
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Return for Revision |
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2020-05-05 19:15 |
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Revised |
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2020-05-11 20:33 |
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Second Decision |
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2020-05-27 09:44 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2020-05-28 21:41 |
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Articles in Press |
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2020-05-28 21:41 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-07-13 02:07 |
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Publish the Manuscript Online |
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2020-07-14 06:33 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Review |
| Article Title |
Sodium-glucose cotransporter 2 inhibitors’ mechanisms of action in heart failure
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Petra Grubić Rotkvić, Maja Cigrovski Berković, Nikola Bulj, Luka Rotkvić and Ivana Ćelap |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Petra Grubić Rotkvić, MD, Doctor, Department of Cardiology, University Hospital, Sveti Duh 64, Zagreb 10000, Croatia. petra.grubic84@gmail.com |
| Key Words |
Sodium-glucose cotransporter 2 inhibitors; Heart failure; Cardiovascular outcomes; Diabetes mellitus; Physiological mechanisms; Pleiotropic effects |
| Core Tip |
Three major cardiovascular outcome trials with a new class of antidiabetic drugs-sodium-glucose cotransporter 2 inhibitors unexpectedly showed that cardiovascular outcomes could be improved due to a reduction in heart failure events. Moreover, recently dapagliflozin was shown to reduce heart failure risk for patients with heart failure with reduced ejection fraction regardless of diabetic status. Currently, there is much doubt regarding the mechanisms of action of these drugs. The most logic explanation is that they are timely targeting various mechanisms underpinning heart failure pathogenesis due to pleiotropic effects which are discussed in the main text. |
| Publish Date |
2020-07-14 06:33 |
| Citation |
Grubić Rotkvić P, Cigrovski Berković M, Bulj N, Rotkvić L, Ćelap I. Sodium-glucose cotransporter 2 inhibitors’ mechanisms of action in heart failure. World J Diabetes 2020; 11(7): 269-279 |
| URL |
https://www.wjgnet.com/1948-9358/full/v11/i7/269.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v11.i7.269 |
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