Publication Name	World Journal of Gastroenterology
Manuscript ID	5462
Country	China

Received	2013-09-10 08:37
Peer-Review Started	2013-09-11 16:57
To Make the First Decision	2013-10-29 12:35
Return for Revision	2013-10-30 10:45
Revised	2013-11-06 15:15
Second Decision	2013-12-05 19:25
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-12-06 12:04
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-01-17 14:46
Typeset the Manuscript	2014-01-22 09:30
Publish the Manuscript Online	2014-02-20 19:40

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Oleanolic acid and ursolic acid inhibit proliferation in transformed rat hepatic oval cells
Manuscript Source	Invited Manuscript
All Author List	Yu-Ying Han, Xiao-Wei Xue, Zheng-Ming Shi, Peng-Yan Wang, Xin-Rui Wu and Xue-Jiang Wang
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Beijing Municipality, China 7112010 National Natural Science Foundation of China 81272757 Education Commission Research Program of Beijing Municipality, China KM201010025004
Corresponding Author	Xue-Jiang Wang, Professor, Department of Pathology and Physiology, Capital Medical University, No. 10, You An Men Xi Tou Tiao, Beijing 100069, China. xj-w@163.com
Key Words	Oxidative stress; Hepatocarcinogenesis; Malignant transformation; Oleanolic acid; Ursolic acid
Core Tip	It is known that H2O2 can promote tumorigenesis. Here, we used H2O2 as a premalignant and malignant agent to induce proliferation and malignant transformation in quiescent rat liver oval cell line WB-F344. Multistage carcinogenic processes provide the basis for interrupting and reversing precancerous changes; therefore, reversing precancerous changes is critical for tumor prevention and treatment. The salient and novel findings of the study are that ursolic acid (UA) and oleanolic acid (OA) induced malignantly transformed WB-F344 cell arrest in the G1 phase and apparently inhibited the proliferation of these cells. These results better our understanding of the antitumor effects of OA and UA.
Publish Date	2014-02-20 19:40
Citation	Han YY, Xue XW, Shi ZM, Wang PY, Wu XR, Wang XJ. Oleanolic acid and ursolic acid inhibit proliferation in transformed rat hepatic oval cells. World J Gastroenterol 2014; 20(5): 1348-1356
URL	http://www.wjgnet.com/1007-9327/full/v20/i5/1348.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i5.1348

Full Article (PDF)	WJG-20-1348.pdf
Full Article (Word)	WJG-20-1348.doc
Manuscript File	5462-Review.doc
Answering Reviewers	5462-Answering reviewers.pdf
Copyright License Agreement	5462-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	5462-Language certificate.pdf
Peer-review Report	5462-Peer review(s).pdf
Scientific Editor Work List	5462-Scientific editor work list.doc