Publication Name	World Journal of Gastroenterology
Manuscript ID	5469
Country	Italy

Received	2013-09-10 09:28
Peer-Review Started	2013-09-11 18:20
First Decision by Editorial Office Director
Return for Revision	2013-10-16 11:12
Revised	2013-11-18 18:33
Publication Fee Transferred
Second Decision by Editor	2014-01-20 16:49
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-01-20 18:03
Articles in Press
Edit the Manuscript by Language Editor	2014-02-25 16:38
Typeset the Manuscript	2014-04-01 10:57
Publish the Manuscript Online	2014-04-17 13:27

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Medicine, General & Internal
Manuscript Type	Topic Highlights
Article Title	Circadian clock circuitry in colorectal cancer
Manuscript Source	Invited Manuscript
All Author List	Gianluigi Mazzoccoli, Manlio Vinciguerra, Gennaro Papa and Ada Piepoli
Funding Agency and Grant Number	Funding Agency Grant Number Italian Ministry of Health through Department of Medical Sciences, Division of Internal Medicine and Chronobiology Unit, IRCCS Scientific Institute and Regional General Hospital “Casa Sollievo della Sofferenza”, Opera di Padre Pio da Pietrelcina, San Giovanni Rotondo (FG), Italy RC1203ME46 (to GM) Italian Ministry of Health through Department of Medical Sciences, Division of Internal Medicine and Chronobiology Unit, IRCCS Scientific Institute and Regional General Hospital “Casa Sollievo della Sofferenza”, Opera di Padre Pio da Pietrelcina, San Giovanni Rotondo (FG), Italy RC1302ME31 (to GM) Italian Ministry of Health through Department of Medical Sciences, Division of Gastroenterology and Research Laboratory RC1203GA55 Italian Ministry of Health through Department of Medical Sciences, Division of Gastroenterology and Research Laboratory RC1203GA56 AIRC MFAG-AIRC2012-13419 (to MV)
Corresponding Author	Gianluigi Mazzoccoli, MD, Department of Medical Sciences, Division of Internal Medicine and Chronobiology Unit, IRCCS Scientific Institute and Regional General Hospital “Casa Sollievo della Sofferenza”, Cappuccini Avenue, 71013 San Giovanni Rotondo Foggia, Italy. g.mazzoccoli@operapadrepio.it
Key Words	Colorectal cancer; Circadian rhythm; Clock gene
Core Tip	The biological clock drives crucial cell processes, such as growth, proliferation, differentiation and apoptosis, controls metabolic pathways, and regulates tissue functions and behavioral cycles. Derangement of these phenomena is involved in colorectal carcinogenesis. The circadian clock circuitry is a leading actor in physiological regulation, a drawn in bystander in colorectal tumorigenesis, and a possible therapeutic target.
Publish Date	2014-04-17 13:27
Citation	Mazzoccoli G, Vinciguerra M, Papa G, Piepoli A. Circadian clock circuitry in colorectal cancer. World J Gastroenterol 2014; 20(15): 4197-4207
URL	http://www.wjgnet.com/1007-9327/full/v20/i15/4197.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i15.4197

Full Article (PDF)	WJG-20-4197.pdf
Full Article (Word)	WJG-20-4197.doc
Manuscript File	5469-Review.doc
Answering Reviewers	5469-Answering reviewers.pdf
Copyright License Agreement	5469-Copyright assignment.pdf
Peer-review Report	5469-Peer reviewers.pdf
Scientific Editor Work List	5469-Scientific editor work list.doc