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Articles Published Processes
9/3/2014 2:27:00 PM | Browse: 920 | Download: 879
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Received |
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2013-09-10 10:31 |
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Peer-Review Started |
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2013-09-11 19:39 |
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To Make the First Decision |
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2013-10-14 20:58 |
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Return for Revision |
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2013-10-15 11:32 |
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Revised |
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2013-10-16 22:23 |
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Second Decision |
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2013-11-01 16:59 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2013-11-03 11:47 |
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Articles in Press |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2013-12-20 22:50 |
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Typeset the Manuscript |
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2013-12-31 17:40 |
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Publish the Manuscript Online |
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2014-02-20 19:40 |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Autobiography |
| Article Title |
Bax protein may influence the invasion of colorectal cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Anna Pryczynicz, Mariusz Gryko, Katarzyna Niewiarowska, Dariusz Cepowicz, Marek Ustymowicz, Andrzej Kemona and Katarzyna Guzińska-Ustymowicz |
| Funding Agency and Grant Number |
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| Corresponding Author |
Anna Pryczynicz, PhD, Department of General Pathomorphology, Medical University of Bialystok, ul. Waszyngtona 13, 15-269 Bialystok, Poland. pryczynicz.anna@gmail.com |
| Key Words |
Bak; Bax; Bcl-xL; Cancer cell infiltration; Colorectal cancer |
| Core Tip |
We determined the expressions of Bax, Bak, and Bcl-xL proteins in colorectal cancer tissue. We reported that low expression of Bax and Bak proteins is related to the localization of the tumor in the rectum, which may explain an increased incidence of colorectal cancer in this area. We also presented the participation of Bax protein in the early stages of colorectal cancer progression. Moreover, our results suggest a greater participation of Bcl-xL protein in the inhibition of the proapoptotic Bak protein, but not the Bax protein. Therefore, Bax protein is probably very significant in the carcinogenesis mechanism in the large intestine. |
| Publish Date |
2014-02-20 19:40 |
| Citation |
Pryczynicz A, Gryko M, Niewiarowska K, Cepowicz D, Ustymowicz M, Kemona A, Guzińska-Ustymowicz K. Bax protein may influence on the invasion of colorectal cancer. World J Gastroenterol 2014; 20(5): 1305-1310 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i5/1305.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i5.1305 |
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