Publication Name	World Journal of Gastroenterology
Manuscript ID	54734
Country	Italy

Received	2020-02-15 18:54
Peer-Review Started	2020-02-15 18:55
To Make the First Decision
Return for Revision	2020-03-15 03:57
Revised	2020-03-21 10:34
Second Decision	2020-03-26 09:04
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2020-03-26 20:58
Articles in Press	2020-03-26 20:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-04-15 13:09
Publish the Manuscript Online	2020-04-21 06:56

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Spontaneous porto-systemic shunts in liver cirrhosis: Clinical and therapeutical aspects
Manuscript Source	Unsolicited Manuscript
All Author List	Silvia Nardelli, Oliviero Riggio, Stefania Gioia, Marta Puzzono, Giuseppe Pelle and Lorenzo Ridola
ORCID	Author(s) ORCID Number Silvia Nardelli http://orcid.org/0000-0002-7038-9539 Oliviero Riggio http://orcid.org/0000-0000-2241-3223 Stefania Gioia http://orcid.org/0000-0002-3940-4390 Marta Puzzono http://orcid.org/0000-0001-9959-9604 Giuseppe Pelle http://orcid.org/0000-0002-5531-6606 Lorenzo Ridola http://orcid.org/0000-0002-8596-2609
Funding Agency and Grant Number
Corresponding Author	Lorenzo Ridola, MD, PhD, Doctor, Doctor, Department of Translational and Precision Medicine, “Sapienza” University of Rome, viale dell’Università 37, Rome 00185, Italy. lorenzo.ridola@uniroma1.it
Key Words	Porto-systemic shunts; Liver cirrhosis; Variceal bleeding; Hepatic encephalopathy; Portal vein thrombosis; Porto-systemic shunt syndrome
Core Tip	Liver cirrhosis is characterized by a progressive increase in portal hypertension and the consequent formation of porto-systemic shunts, that act as “release valves” to reduce the portal pressure, but also act as bypasses to normal liver flow. As the shunt becomes large enough, the complications appear including hepatic encephalopathy, variceal bleeding, portal vein thrombosis and the deterioration of liver function.
Publish Date	2020-04-21 06:56
Citation	Nardelli S, Riggio O, Gioia S, Puzzono M, Pelle G, Ridola L. Spontaneous porto-systemic shunts in liver cirrhosis: Clinical and therapeutical aspects. World J Gastroenterol 2020; 26(15): 1726-1732
URL	https://www.wjgnet.com/1007-9327/full/v26/i15/1726.htm
DOI	https://dx.doi.org/10.3748/wjg.v26.i15.1726

Full Article (PDF)	WJG-26-1726.pdf
Full Article (Word)	WJG-26-1726.docx
Manuscript File	54734-Review.doc
Answering Reviewers	54734-Answering reviewers.pdf
Audio Core Tip	54734-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	54734-Conflict-of-interest statement.pdf
Copyright License Agreement	54734-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	54734-Language certificate.pdf
Peer-review Report	54734-Peer-review(s).pdf
Scientific Misconduct Check	54734-Scientific misconduct check.pdf
Scientific Editor Work List	54734-Scientific editor work list.pdf
CrossCheck Report	54734-CrossCheck report.pdf