Publication Name	World Journal of Gastroenterology
Manuscript ID	54758
Country	China

Received	2020-02-17 09:30
Peer-Review Started	2020-02-17 09:31
To Make the First Decision
Return for Revision	2020-03-18 04:19
Revised	2020-03-26 11:26
Second Decision	2020-04-26 10:22
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2020-04-26 19:10
Articles in Press	2020-04-26 19:10
Publication Fee Transferred
Edit the Manuscript by Language Editor	2020-05-14 02:43
Typeset the Manuscript	2020-05-27 08:44
Publish the Manuscript Online	2020-06-06 14:43

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Gan Shen Fu Fang ameliorates liver fibrosis in vitro and in vivo by inhibiting the inflammatory response and extracellular signal-regulated kinase phosphorylation
Manuscript Source	Unsolicited Manuscript
All Author List	Qing-Hong Du, Chu-Jun Zhang, Wei-Hong Li, Yan Mu, Ya Xu, Scott Lowe, Lin Han, Xue Yu, Shu-Yan Wang, Yu Li and Jian Li
ORCID	Author(s) ORCID Number Qing-Hong Du http://orcid.org/0000-0002-3753-5995 Chu-Jun Zhang http://orcid.org/0000-0002-3712-5873 Wei-Hong Li http://orcid.org/0000-0003-3562-6532 Yan Mu http://orcid.org/0000-0002-5010-7741 Ya Xu http://orcid.org/0000-0003-0272-9703 Scott Lowe http://orcid.org/0000-0002-1711-5766 Lin Han http://orcid.org/0000-0002-0328-7428 Xue Yu http://orcid.org/0000-0002-7703-0764 Shu-Yan Wang http://orcid.org/0000-0002-7400-7550 Yu Li http://orcid.org/0000-0002-9077-9294 Jian Li http://orcid.org/0000-0002-8864-0621
Funding Agency and Grant Number	Funding Agency Grant Number Innovation Team of the Beijing University of Chinese Medicine 2019-JYB-TD-006 National Natural Science Foundation of China 81873099 Scientific Research Support Plan for the Construction of Doctoral Program of University of Tibetan Medicine
Corresponding Author	Jian Li, PhD, Professor, Teacher, Department of histology and embryology, School of Traditional Chinese medicine, Beijing University of Chinese Medicine, No. 11 Bei san huan dong Road, Beijing 102488, China. lijian@bucm.edu.cn
Key Words	Liver fibrosis; Gan Shen Fu Fang; Inflammatory response; Extracellular signal-regulated kinase phosphorylation; In vivo; In vitro
Core Tip	Liver fibrosis is the final result of various kinds of chronic liver disease and there is no specific strategy so far. Inflammatory response and extracellular signal-regulated kinase cascade play an important part in liver fibrosis development and progression. In this study, we observe the effects of herbal medicine, Gan Shen Fu Fang (GSFF) on liver fibrosis in vivo and in vitro. The results indicate that GSFF alleviates liver fibrosis progression in vivo and inhibits HSC-T6 activation in vitro, which may be related with inhibited inflammatory response and downregulated extracellular signal-regulated kinase phosphorylation. GSFF may provide hope for liver fibrosis treatment.
Publish Date	2020-06-06 14:43
Citation	Du QH, Zhang CJ, Li WH, Mu Y, Xu Y, Lowe S, Han L, Yu X, Wang SY, Li Y, Li J. Gan Shen Fu Fang ameliorates liver fibrosis in vitro and in vivo by inhibiting the inflammatory response and extracellular signal-regulated kinase phosphorylation. World J Gastroenterol 2020; 26(21): 2810-2820
URL	https://www.wjgnet.com/1007-9327/full/v26/i21/2810.htm
DOI	https://dx.doi.org/10.3748/wjg.v26.i21.2810

Full Article (PDF)	WJG-26-2810.pdf
Full Article (Word)	WJG-26-2810.docx
Manuscript File	54758-Review-Ma JY.docx
Answering Reviewers	54758-Answering reviewers.pdf
Audio Core Tip	54758-Audio core tip.mp3
Biostatistics Review Certificate	54758-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	54758-Conflict-of-interest statement.pdf
Copyright License Agreement	54758-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	54758-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	54758-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	54758-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	54758-Language certificate.pdf
Peer-review Report	54758-Peer-review(s).pdf
Scientific Misconduct Check	54758-Bing-Tang JZ-2.png
Scientific Misconduct Check	54758-Scientific misconduct check.pdf
Scientific Editor Work List	54758-Scientific editor work list.pdf
CrossCheck Report	54758-CrossCheck Report.pdf