Publication Name	World Journal of Gastroenterology
Manuscript ID	5482
Country	Norway

Received	2013-09-10 12:01
Peer-Review Started	2013-09-12 16:11
To Make the First Decision	2013-10-14 20:58
Return for Revision	2013-10-15 11:31
Revised	2013-10-20 07:04
Second Decision	2013-11-18 21:08
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-11-19 12:26
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-02-19 18:46
Publish the Manuscript Online	2014-03-06 14:13

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Endocrine cells in the ileum of patients with irritable bowel syndrome
Manuscript Source	Invited Manuscript
All Author List	Magdy El-Salhy, Odd Helge Gilja, Doris Gundersen, Jan Gunnar Hatlebakk and Trygve Hausken
Funding Agency and Grant Number	Funding Agency Grant Number Helse-Fonna
Corresponding Author	Magdy El-Salhy, Professor, Consultant Gastroenterologist, Section for Gastroenterology, Department of Medicine, Stord Helse-Fonna Hospital, Box 4000, 54 09 Stord, Norway. magdy.el-salhy@helse-fonna.no
Key Words	Computer image analysis; Irritable bowel syndrome; Ileum; Peptide YY; Serotonin
Core Tip	The present study investigated for the first time the ileal endocrine cells in patients with irritable bowel syndrome (IBS). It included a relatively a large cohort of patients and comprising all the IBS subtypes, namely diarrhea (IBS-D), a mixture of both diarrhea and constipation (IBS-M) and constipation (IBS-C). It showed that the density of serotonin cells is reduced in patients with IBS, regardless of the subtype. On the other hand the density of peptide YY (PYY) cells in the ileum of IBS-D and IBS-M patients did not differ from that of controls, but was significantly elevated in those with IBS-C. It was concluded that the reduction of ileal serotonin cells may be connected to the visceral hypersensitivity seen in all IBS subtypes and that increase in the PYY cell density in IBS-C, would slow the intestinal transit and cause constipation.
Publish Date	2014-03-06 14:13
Citation	El-Salhy M, Gilja OH, Gundersen D, Hatlebakk JG, Hausken T. Endocrine cells in the ileum of patients with irritable bowel syndrome. World J Gastroenterol 2014; 20(9): 2383-2391
URL	http://www.wjgnet.com/1007-9327/full/v20/i9/2383.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i9.2383

Full Article (PDF)	WJG-20-2383.pdf
Full Article (Word)	WJG-20-2383.doc
Manuscript File	5482-Review.doc
Answering Reviewers	5482-Answering Reviewers.pdf
Copyright License Agreement	5482-Copyright Assignment.pdf
Peer-review Report	5482-Peer Review(s).pdf
Scientific Editor Work List	5482-Scientific editor work list.doc