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9/2/2014 10:31:00 AM | Browse: 456 | Download: 353
Publication Name World Journal of Gastroenterology
Manuscript ID 5482
Country/Territory Norway
Received
2013-09-10 12:01
Peer-Review Started
2013-09-12 16:11
To Make the First Decision
2013-10-14 20:58
Return for Revision
2013-10-15 11:31
Revised
2013-10-20 07:04
Second Decision
2013-11-18 21:08
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-11-19 12:26
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-02-19 18:46
Publish the Manuscript Online
2014-03-06 14:13
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Autobiography
Article Title Endocrine cells in the ileum of patients with irritable bowel syndrome
Manuscript Source Invited Manuscript
All Author List Magdy El-Salhy, Odd Helge Gilja, Doris Gundersen, Jan Gunnar Hatlebakk and Trygve Hausken
Funding Agency and Grant Number
Funding Agency Grant Number
Helse-Fonna
Corresponding author Magdy El-Salhy, Professor, Consultant Gastroenterologist, Section for Gastroenterology, Department of Medicine, Stord Helse-Fonna Hospital, Box 4000, 54 09 Stord, Norway. magdy.el-salhy@helse-fonna.no
Keywords Computer image analysis; Irritable bowel syndrome; Ileum; Peptide YY; Serotonin
Core Tip The present study investigated for the first time the ileal endocrine cells in patients with irritable bowel syndrome (IBS). It included a relatively a large cohort of patients and comprising all the IBS subtypes, namely diarrhea (IBS-D), a mixture of both diarrhea and constipation (IBS-M) and constipation (IBS-C). It showed that the density of serotonin cells is reduced in patients with IBS, regardless of the subtype. On the other hand the density of peptide YY (PYY) cells in the ileum of IBS-D and IBS-M patients did not differ from that of controls, but was significantly elevated in those with IBS-C. It was concluded that the reduction of ileal serotonin cells may be connected to the visceral hypersensitivity seen in all IBS subtypes and that increase in the PYY cell density in IBS-C, would slow the intestinal transit and cause constipation.
Publish Date 2014-03-06 14:13
Citation El-Salhy M, Gilja OH, Gundersen D, Hatlebakk JG, Hausken T. Endocrine cells in the ileum of patients with irritable bowel syndrome. World J Gastroenterol 2014; 20(9): 2383-2391
Url http://www.wjgnet.com/1007-9327/full/v20/i9/2383.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i9.2383
Full Article (PDF) WJG-20-2383.pdf
Full Article (Word) WJG-20-2383.doc
Manuscript File 5482-Review.doc
Answering Reviewers 5482-Answering Reviewers.pdf
Copyright License Agreement 5482-Copyright Assignment.pdf
Peer-review Report 5482-Peer Review(s).pdf
Scientific Editor Work List 5482-Scientific editor work list.doc