Publication Name	World Journal of Gastroenterology
Manuscript ID	5495
Country	Denmark

Received	2013-09-11 09:11
Peer-Review Started	2013-09-13 11:27
To Make the First Decision	2013-10-29 12:29
Return for Revision	2013-11-04 19:14
Revised	2013-11-18 00:37
Second Decision	2014-01-02 10:54
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-01-02 12:01
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-01-12 23:49
Typeset the Manuscript	2014-02-20 18:29
Publish the Manuscript Online	2014-04-29 09:53

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Topic Highlights
Article Title	Role of human epidermal growth factor receptor 2 in gastric cancer: Biological and pharmacological aspects
Manuscript Source	Invited Manuscript
All Author List	Jan Trøst Jørgensen
Funding Agency and Grant Number
Corresponding Author	Jan Trost Jorgensen, MSc Pharm, PhD, Dx-Rx Institute, Baunevaenget 76, 3480 Fredensborg, Denmark. jan.trost@dx-rx.dk
Key Words	Human epidermal growth factor receptor 2; Gastric cancer; Prognostic; Companion diagnostics; Trastuzumab; Pertuzumab; Ado-trastuzumab emtansine; Lapatinib
Core Tip	Amplification of the human epidermal growth factor receptor 2 (HER2) gene and overexpression of the HER2 protein can be detected in 15%-20% of patients with gastric and gastroesophageal junction (GEJ) cancer. Recently, HER2 has proven to be an important target for treatment with trastuzumab in these patients, and a positive HER2 status seems to possess both prognostic and predictive properties. A number of new compounds directed towards HER2 and other members of the HER family is currently under development. This review will discuss the current status of HER2 in gastric and GEJ cancer and the future direction in relation to HER2 target therapy.
Publish Date	2014-04-29 09:53
Citation	Jørgensen JT. Role of human epidermal growth factor receptor 2 in gastric cancer: Biological and pharmacological aspects. World J Gastroenterol 2014; 20(16): 4526-4535
URL	http://www.wjgnet.com/1007-9327/full/v20/i16/4526.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i16.4526

Full Article (PDF)	WJG-20-4526.pdf
Full Article (Word)	WJG-20-4526.doc
Manuscript File	5495-Review.docx
Answering Reviewers	5495-Answering reviewers.pdf
Copyright License Agreement	5495-Copyright assignment.pdf
Peer-review Report	5495-Peer review(s).pdf
Scientific Editor Work List	5495-Scientific editor work list.doc