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7/20/2020 2:28:50 AM | Browse: 732 | Download: 803
Publication Name World Journal of Clinical Oncology
Manuscript ID 54967
Country/Territory Italy
Received
2020-02-28 17:27
Peer-Review Started
2020-03-02 04:23
To Make the First Decision
Return for Revision
2020-04-02 17:14
Revised
2020-05-08 19:43
Second Decision
2020-05-25 07:58
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-05-27 19:02
Articles in Press
2020-05-27 19:02
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-06-11 06:26
Typeset the Manuscript
2020-07-14 23:37
Publish the Manuscript Online
2020-07-20 02:28
ISSN 2218-4333 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Review
Article Title MUTYH: Not just polyposis
Manuscript Source Invited Manuscript
All Author List Maria Cristina Curia, Teresa Catalano and Gitana Maria Aceto
ORCID
Author(s) ORCID Number
Maria Cristina Curia http://orcid.org/0000-0003-4979-887X
Teresa Catalano http://orcid.org/0000-0001-6713-3818
Gitana Maria Aceto http://orcid.org/0000-0002-6845-1321
Funding Agency and Grant Number
Corresponding Author Maria Cristina Curia, DSc, Associate Professor, Department of Medical, Oral and Biotechnological Sciences, “G. d'Annunzio” University of Chieti-Pescara, Via dei Vestini, Chieti 66100, Italy. mc.curia@unich.it
Key Words MUTYH; Polyposis; Colorectal cancer; Base excision repair; Mutations; Single nucleotide polymorphism
Core Tip This review focuses on the role of MUTYH, linked to MUTYH associated polyposis syndrome, on human neoplastic and non-neoplastic diseases, different from polyposis and colorectal cancer, considering its involvement in disorders based on oxidative stress damage. MUTYH pathogenic variants represent an independent predictor of poor prognosis in sporadic gastric, salivary gland secretory, pancreatic ductal, lung and cervical cancers, whereas some variants are involved in degenerative disorders, including neurological and ocular diseases. This provides novel insights to identify the molecular basis of MUTYH pathogenesis at the light of recent advances, to better understand its potential in the disease prevention and identify new therapeutic targets.
Publish Date 2020-07-20 02:28
Citation Curia MC, Catalano T, Aceto GM. MUTYH: Not just polyposis. World J Clin Oncol 2020; 11(7): 428-449
URL https://www.wjgnet.com/2218-4333/full/v11/i7/428.htm
DOI https://dx.doi.org/10.5306/wjco.v11.i7.428
Full Article (PDF) WJCO-11-428.pdf
Full Article (Word) WJCO-11-428.docx
Manuscript File 54967-Review-Webster J.docx
Answering Reviewers 54967-Answering reviewers.pdf
Audio Core Tip 54967-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 54967-Conflict-of-interest statement.pdf
Copyright License Agreement 54967-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 54967-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 54967-Language certificate.pdf
Peer-review Report 54967-Peer-review(s).pdf
Scientific Misconduct Check 54967-Scientific misconduct check.pdf
Scientific Editor Work List 54967-Scientific editor work list.pdf