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Articles Published Processes
7/20/2020 2:28:50 AM | Browse: 870 | Download: 1278
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Received |
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2020-02-28 17:27 |
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Peer-Review Started |
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2020-03-02 04:23 |
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To Make the First Decision |
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Return for Revision |
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2020-04-02 17:14 |
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Revised |
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2020-05-08 19:43 |
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Second Decision |
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2020-05-25 07:58 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-05-27 19:02 |
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Articles in Press |
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2020-05-27 19:02 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-06-11 06:26 |
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Typeset the Manuscript |
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2020-07-14 23:37 |
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Publish the Manuscript Online |
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2020-07-20 02:28 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
MUTYH: Not just polyposis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Maria Cristina Curia, Teresa Catalano and Gitana Maria Aceto |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Maria Cristina Curia, DSc, Associate Professor, Department of Medical, Oral and Biotechnological Sciences, “G. d'Annunzio” University of Chieti-Pescara, Via dei Vestini, Chieti 66100, Italy. mc.curia@unich.it |
| Key Words |
MUTYH; Polyposis; Colorectal cancer; Base excision repair; Mutations; Single nucleotide polymorphism |
| Core Tip |
This review focuses on the role of MUTYH, linked to MUTYH associated polyposis syndrome, on human neoplastic and non-neoplastic diseases, different from polyposis and colorectal cancer, considering its involvement in disorders based on oxidative stress damage. MUTYH pathogenic variants represent an independent predictor of poor prognosis in sporadic gastric, salivary gland secretory, pancreatic ductal, lung and cervical cancers, whereas some variants are involved in degenerative disorders, including neurological and ocular diseases. This provides novel insights to identify the molecular basis of MUTYH pathogenesis at the light of recent advances, to better understand its potential in the disease prevention and identify new therapeutic targets. |
| Publish Date |
2020-07-20 02:28 |
| Citation |
Curia MC, Catalano T, Aceto GM. MUTYH: Not just polyposis. World J Clin Oncol 2020; 11(7): 428-449 |
| URL |
https://www.wjgnet.com/2218-4333/full/v11/i7/428.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v11.i7.428 |
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