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Articles Published Processes
5/24/2020 11:59:07 AM | Browse: 1035 | Download: 2252
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Received |
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2020-02-27 10:18 |
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Peer-Review Started |
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2020-02-27 10:26 |
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First Decision by Editorial Office Director |
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2020-04-07 23:26 |
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Return for Revision |
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2020-04-07 23:26 |
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Revised |
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2020-04-13 08:12 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2020-05-12 08:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2020-05-13 06:24 |
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Articles in Press |
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2020-05-13 06:24 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-05-21 11:15 |
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Publish the Manuscript Online |
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2020-05-24 11:59 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
CITED2 and the modulation of the hypoxic response in cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Mónica T Fernandes, Sofia M Calado, Leonardo Mendes-Silva and José Bragança |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
José Bragança, PhD, Assistant Professor, Department of Biomedical Sciences and Medicine, CBMR-Centre for BioMedical Research, Universidade do Algarve, Campus of Gambelas, Building 8, Room 2.22, Faro 8005139, Portugal. jebraganca@ualg.pt |
| Key Words |
Cancer; Cancer stem cell; CBP/p300; CITED2; Hypoxia-inducible factors 1α; Hypoxia |
| Core Tip |
Hypoxia is a common feature of many cancers. In response to hypoxia, hypoxia-inducible factor 1 (HIF-1) is stabilized and activates downstream target-genes participating in crucial aspects of cancer biology, such as angiogenesis, cell survival, glucose metabolism and invasion. CITED2 is a negative regulator of HIF with demonstrated roles in various types of cancer. Therefore, CITED2 can potentially modulate HIF effects in cancer and constitute a novel target for therapies. Herein, we compile the roles reported for CITED2 in health and disease, namely through the modulation of HIF activity. We also discuss the various context-dependent roles for CITED2 in cancer. |
| Publish Date |
2020-05-24 11:59 |
| Citation |
Fernandes MT, Calado SM, Mendes-Silva L, Bragança J. CITED2 and the modulation of the hypoxic response in cancer. World J Clin Oncol 2020; 11(5): 260-274 |
| URL |
https://www.wjgnet.com/2218-4333/full/v11/i5/260.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v11.i5.260 |
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