Publication Name	World Journal of Clinical Cases
Manuscript ID	55006
Country	China

Received	2020-02-29 07:26
Peer-Review Started	2020-02-29 07:27
To Make the First Decision
Return for Revision	2020-04-02 23:16
Revised	2020-05-09 04:59
Second Decision	2020-08-07 08:29
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-08-09 04:58
Articles in Press	2020-08-09 04:58
Publication Fee Transferred
Edit the Manuscript by Language Editor	2020-08-17 05:59
Typeset the Manuscript	2020-08-31 09:39
Publish the Manuscript Online	2020-09-04 08:47

ISSN	2307-8960 (online)
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Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Active surveillance in metastatic pancreatic neuroendocrine tumors: A 20-year single-institutional experience
Manuscript Source	Invited Manuscript
All Author List	He-Li Gao, Wen-Quan Wang, Hua-Xiang Xu, Chun-Tao Wu, Hao Li, Quan-Xing Ni, Xian-Jun Yu and Liang Liu
ORCID	Author(s) ORCID Number He-Li Gao http://orcid.org/0000-0001-6094-5776 Wen-Quan Wang http://orcid.org/0000-0001-9434-8013 Hua-Xiang Xu http://orcid.org/0000-0002-5346-2335 Chun-Tao Wu http://orcid.org/0000-0003-1147-0887 Hao Li http://orcid.org/0000-0002-1624-8970 Quan-Xing Ni http://orcid.org/0000-0003-1877-8067 Xian-Jun Yu http://orcid.org/0000-0002-6697-7143 Liang Liu http://orcid.org/0000-0002-8003-0503
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81802675 National Natural Science Foundation of China 81871941 National Natural Science Foundation of China 81872366 National Natural Science Foundation of China 81827807 National Natural Science Foundation of China 81702341 National Science Foundation for Distinguished Young Scholars of China 8162500008 Outstanding Academic Leader Program of the Technological Innovation Action Plan in Shanghai Science and Technology Commission 18XD1401200 Young Talented Specialist Training Program of Shanghai 19ZR1410800
Corresponding Author	Liang Liu, MD, PhD, Professor, Surgeon, Surgical Oncologist, Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, No. 270, Dong An Road, Shanghai 200032, China. liuliang@fudanpci.org
Key Words	Pancreatic neuroendocrine tumor; Liver metastasis; Active surveillance; Prognosis; Nomogram;
Core Tip	Active surveillance in metastasis pancreatic neuroendocrine tumors (PanNET) lacks sufficient experience in clinical practice. This study contained 20-year experience of active surveillance in 76 patients with liver metastatic nonfunctioning PanNET (NF-PanNET). We demonstrated that largest axis of the liver metastasis>5mm, non-resection of the primary tumor and T3-4 stage are the poor prognostic factors that affecting survival of PanNET with liver metastasis. Patients with favorable factors had a time to progressive disease of more than two years without systemic treatment. This subset of PanNET with liver metastatic may attempt to undergo active surveillance.
Publish Date	2020-09-04 08:47
Citation	Gao HL, Wang WQ, Xu HX, Wu CT, Li H, Ni QX, Yu XJ, Liu L. Active surveillance in metastatic pancreatic neuroendocrine tumors: A 20-year single-institutional experience. World J Clin Cases 2020; 8(17): 3751-3762
URL	https://www.wjgnet.com/2307-8960/full/v8/i17/3751.htm
DOI	https://dx.doi.org/10.12998/wjcc.v8.i17.3751

Full Article (PDF)	WJCC-8-3751.pdf
Full Article (Word)	WJCC-8-3751.docx
Manuscript File	55006-Review-Webster J.docx
Answering Reviewers	55006-Answering reviewers.pdf
Audio Core Tip	55006-Audio core tip.m4a
Biostatistics Review Certificate	55006-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	55006-Conflict-of-interest statement.pdf
Copyright License Agreement	55006-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	55006-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	55006-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	55006-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	55006-Language certificate.pdf
Peer-review Report	55006-Peer-review(s).pdf
Scientific Misconduct Check	55006-Bing-Wang J-1.png
Scientific Misconduct Check	55006-Bing-Liu M-2.png
Scientific Misconduct Check	55006-Scientific misconduct check.pdf
Scientific Editor Work List	55006-Scientific editor work list.pdf