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Articles Published Processes
8/26/2020 5:49:13 AM | Browse: 797 | Download: 1523
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Received |
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2020-02-28 13:18 |
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Peer-Review Started |
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2020-02-28 13:20 |
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To Make the First Decision |
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Return for Revision |
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2020-04-25 21:21 |
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Revised |
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2020-05-17 15:58 |
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Second Decision |
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2020-06-19 09:59 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-06-20 22:58 |
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Articles in Press |
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2020-06-20 22:58 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-06-25 03:32 |
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Typeset the Manuscript |
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2020-08-14 00:11 |
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Publish the Manuscript Online |
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2020-08-26 05:49 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Review |
| Article Title |
Autophagy in fate determination of mesenchymal stem cells and bone remodeling
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Xiao-Dan Chen, Jia-Li Tan, Yi Feng, Li-Jia Huang, Mei Zhang and Bin Cheng |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81873710 |
| National Natural Science Foundation of China |
81900976 |
| Guangzhou Foundation for Science and Technology Planning Project, China |
201704030083 |
| Guangzhou Foundation for Science and Technology Planning Project, China |
201704020063 |
| Guangdong Financial Fund for High-Caliber Hospital Construction |
174-2018-XMZC-0001-03-0125/C-05 |
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| Corresponding Author |
Bin Cheng, DDS, PhD, Professor, Department of Oral Medicine, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University and Guangdong Provincial Key Laboratory of Stomatology, No. 56 Lingyuanxi Road, Guangzhou 510055, Guangdong Province, China. chengbin@mail.sysu.edu.cn |
| Key Words |
Mesenchymal stem cells; Autophagy; Cell self-renewal; Cell differentiation; Cytoprotection; Bone remodeling |
| Core Tip |
Autophagy is a dynamic recycling mechanism that fuels cellular renovation and homeostasis. Recent studies have shed light on an essential role of autophagy in orchestrating self-renewal and the multilineage differentiation potential of mesenchymal stem cells (MSCs), thus coordinating bone homeostasis. This review outlines the effects of autophagy on MSCs fate determination and cytoprotection under different kinds of stresses. Moreover, we emphasize that the involvement of autophagy ensures balanced bone remodeling, which will be of significance in facilitating its application as a therapeutic target in bone repair and regeneration. |
| Publish Date |
2020-08-26 05:49 |
| Citation |
Chen XD, Tan JL, Feng Y, Huang LJ, Zhang M, Cheng B. Autophagy in fate determination of mesenchymal stem cells and bone remodeling. World J Stem Cells 2020; 12(8): 776-786 |
| URL |
https://www.wjgnet.com/1948-0210/full/v12/i8/776.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v12.i8.776 |
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