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Articles Published Processes
8/21/2020 1:38:19 AM | Browse: 766 | Download: 1268
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Received |
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2020-02-28 14:54 |
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Peer-Review Started |
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2020-02-28 14:55 |
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To Make the First Decision |
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Return for Revision |
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2020-04-25 21:20 |
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Revised |
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2020-06-04 13:01 |
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Second Decision |
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2020-06-19 10:04 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-06-20 22:55 |
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Articles in Press |
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2020-06-20 22:55 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-06-30 05:42 |
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Typeset the Manuscript |
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2020-08-03 00:49 |
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Publish the Manuscript Online |
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2020-08-21 01:38 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Novel molecular targets in hepatocellular carcinoma
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ariel Ka-Man Chow, Simon Wing-Lung Yau and Lui Ng |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Lui Ng, PhD, Research Assistant Professor, Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong , China. luing@hku.hk |
| Key Words |
Hepatocellular carcinoma; Prognosis arginine deprivation; Cancer stem cells; Glypican-3; Hedgehog signaling pathway; Histone deacetylases; Personalized medicine; Molecular targeted therapy; Notch signaling pathway; Polo-like kinase 1; Tumour-associated antigens |
| Core Tip |
Hepatocellular carcinoma (HCC) remains a critical concern worldwide owing to the severity of disease outcome. Primary cause is the low efficacy of current therapeutic regimens available to treat advanced HCC. This review details novel potentially vulnerable targets in the oncogenic signaling pathways associated with HCC development and progression, that should be targeted to develop molecular combination therapies to improve disease management. Moreover, identification and establishment of novel biomarkers would complement this process in assisting timely management of the disease via powerful personalized drug regimens. |
| Publish Date |
2020-08-21 01:38 |
| Citation |
Chow AKM, Yau SWL, Ng L. Novel molecular targets in hepatocellular carcinoma. World J Clin Oncol 2020; 11(8): 589-605 |
| URL |
https://www.wjgnet.com/2218-4333/full/v11/i8/589.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v11.i8.589 |
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