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Articles Published Processes
7/26/2020 8:24:58 AM | Browse: 976 | Download: 2586
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Received |
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2020-02-28 22:20 |
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Peer-Review Started |
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2020-02-28 22:22 |
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First Decision by Editorial Office Director |
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2020-04-18 21:19 |
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Return for Revision |
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2020-04-18 21:19 |
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Revised |
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2020-05-19 16:07 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2020-06-08 09:13 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2020-06-10 20:06 |
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Articles in Press |
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2020-06-10 20:06 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-07-24 08:43 |
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Publish the Manuscript Online |
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2020-07-26 08:24 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Involvement of glycated albumin in adipose-derived-stem cell-mediated interleukin 17 secreting T helper cell activation
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Julien Pestel, Maud Robert, Sara Corbin, Hubert Vidal and Assia Eljaafari |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Assia Eljaafari, MD, PhD, Doctor, Doctor, Senior Scientist, CarMeN laboratory, INSERM U1060, University Claude Bernard Lyon 1 and Hospices Civils de Lyon, Batiment CENS-ELI, Centre Hospitalier Lyon Sud, 165 chemin du Grand Revoyet, Pierre Bénite 69310, France. assia.eljaafari@univ-lyon1.fr |
| Key Words |
Interleukin 17 secreting T cells; Lean adipose tissue; Type 1 diabetes; Advanced glycation end products; Adipose-derived stem cells; |
| Core Tip |
Using a coculture model with human lean adipose-derived stem cells (ASC) and mononuclear cells, we have shown in this study that glycated human serum albumin (G-HSA) enhances lean ASC-mediated interleukin (IL)-17A, interferon gamma and tumor necrosis factor alpha secretion. This effect involved the advanced glycated end products (AGE)/Receptor of advanced glycated end products (RAGE) axis as assessed by anti-RAGE blocking antibodies and was associated with increased expression of RAGE and human leukocyte antigen-DR molecules. Thus, our results demonstrated that G-HSA potentiated lean ASC-mediated IL-17A production in adipose tissues, suggesting a new mechanism by which AGE could contribute to type 1 diabetes pathophysiology. |
| Publish Date |
2020-07-26 08:24 |
| Citation |
Pestel J, Robert M, Corbin S, Vidal H, Eljaafari A. Involvement of Glycated Albumin in adipose-derived-stem cell-mediated Th17 cell activation. World J Stem Cells 2020; 12(7): 621-632
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| URL |
https://www.wjgnet.com/1948-0210/full/v12/i7/621.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v12.i7.621 |
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