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9/22/2020 3:17:13 AM | Browse: 339 | Download: 780
Publication Name World Journal of Clinical Cases
Manuscript ID 55085
Country/Territory Brazil
2020-03-21 14:32
Peer-Review Started
2020-03-21 14:37
To Make the First Decision
Return for Revision
2020-04-08 16:44
2020-04-23 23:37
Second Decision
2020-07-28 10:25
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-07-30 05:05
Articles in Press
2020-07-30 05:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-08-24 03:16
Typeset the Manuscript
2020-09-15 17:04
Publish the Manuscript Online
2020-09-22 03:17
ISSN 2307-8960 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Medicine, Research and Experimental
Manuscript Type Systematic Reviews
Article Title Primary sclerosing cholangitis and autoimmune hepatitis overlap syndrome associated with inflammatory bowel disease: A case report and systematic review
Manuscript Source Invited Manuscript
All Author List Vinícius Remus Ballotin, Lucas Goldmann Bigarella, Floriano Riva, Georgia Onzi, Raul Angelo Balbinot, Silvana Sartori Balbinot and Jonathan Soldera
Author(s) ORCID Number
Vinícius Remus Ballotin http://orcid.org/0000-0002-2659-2249
Lucas Goldmann Bigarella http://orcid.org/0000-0001-8087-0070
Floriano Riva http://orcid.org/0000-0002-2262-3968
Georgia Onzi http://orcid.org/0000-0003-0350-4936
Raul Angelo Balbinot http://orcid.org/0000-0003-4705-0702
Silvana Sartori Balbinot http://orcid.org/0000-0002-5026-1028
Jonathan Soldera http://orcid.org/0000-0001-6055-4783
Funding Agency and Grant Number
Corresponding Author Jonathan Soldera, MD, MSc, Associate Professor, Staff Physician, Clinical Gastroenterology, Universidade de Caxias do Sul, Rua Francisco Getúlio Vargas 1130, Caxias do Sul 95084180, Brazil. jonathansoldera@gmail.com
Key Words Autoimmune hepatitis; Primary sclerosing cholangitis; Crohn’s disease; Ulcerative colitis; Inflammatory bowel diseases;
Core Tip We have aimed to report a case of a female patient with autoimmune hepatitis (AIH) and primary sclerosing cholangitis (PSC) overlap syndrome associated to ulcerative colitis and to systematically review the available cases of AIH and PSC overlap syndrome. A previously healthy 22-year-old woman presented with abdominal pain and jaundice. She had a reagent antinuclear factor (1:640, with a homogeneous nuclear pattern). Magnetic resonance cholangiography showed a cirrhotic liver with multiple focal areas of strictures of the intrahepatic bile ducts, with associate dilations. Liver biopsy described periportal necroinflammatory activity, plasmocyte infiltration, and advanced fibrosis. Colonoscopy had shown ulcerative pancolitis and mild activity (Mayo score 1), with a spared rectum. Treatment with corticosteroids, azathioprine, ursodeoxycholic acid and mesalamine was begun, with improvement in laboratory tests. Searches for the systematic review were run on seven electronic databases, retrieving 3349 references. In the final analysis, 44 references were included, with a total of 109 cases reported. The most common clinical finding was jaundice and 43.5% of cases were associated with inflammatory bowel disease. Among these, 27.6% were cases of Crohn’s disease, 68% of ulcerative colitis, and 6.4% of indeterminate colitis. Most patients were treated with steroids. All-cause mortality was 3.7%. In conclusion, PSC and AIH overlap syndrome is generally associated with inflammatory bowel disease and is associated with low mortality and good response to treatment.
Publish Date 2020-09-22 03:17
Citation Ballotin VR, Bigarella LG, Riva F, Onzi G,Balbinot RA, Balbinot SS, Soldera J. Primary sclerosing cholangitis and autoimmune hepatitis overlap syndrome associated with inflammatory bowel disease: A case report and systematic review. World J Clin Cases 2020; 8(18): 4075-4093
URL https://www.wjgnet.com/2307-8960/full/v8/i18/4075.htm
DOI https://dx.doi.org/10.12998/wjcc.v8.i18.4075
Full Article (PDF) WJCC-8-4075.pdf
Full Article (Word) WJCC-8-4075.docx
Manuscript File 55085-Review-Webster J.docx
Answering Reviewers 55085-Answering reviewers.pdf
Audio Core Tip 55085-Audio core tip.opus
Biostatistics Review Certificate 55085-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 55085-Conflict-of-interest statement.pdf
Copyright License Agreement 55085-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 55085-Language certificate.pdf
Supplementary Material 55085-Supplementary material.pdf
Peer-review Report 55085-Peer-review(s).pdf
Scientific Misconduct Check 55085-Bing-Tang JZ-1.png
Scientific Misconduct Check 55085-Scientific misconduct check.pdf
Scientific Editor Work List 55085-Scientific editor work list.pdf