| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Surgery |
| Manuscript Type |
Basic Study |
| Article Title |
Sleeve gastrectomy ameliorates endothelial function and prevents lung cancer by normalizing endothelin-1 axis in obese and diabetic rats
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Rexiati Ruze, Ya-Cheng Xiong, Jian-Wen Li, Ming-Wei Zhong, Qian Xu, Zhi-Bo Yan, Jian-Kang Zhu, Yu-Gang Cheng, San-Yuan Hu and Guang-Yong Zhang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81370496 |
| National Natural Science Foundation of China |
81873647 |
| Youth Program of National Natural Science Foundation of China |
81600059 |
|
| Corresponding Author |
Guang-Yong Zhang, DSc, MD, PhD, Chief Doctor, Professor, Department of General Surgery, The First Affiliated Hospital of Shandong First Medical University, No. 16766, Jingshi Road, Jinan 250014, Shandong Province, China. guangyongzhang@hotmail.com |
| Key Words |
Sleeve gastrectomy; Lung cancer; Endothelin-1 axis; Endothelial dysfunction; DNA damage; Obesity |
| Core Tip |
To explore the potential mechanism of bariatric surgery declining the risk of cancer, sleeve gastrectomy (SG) was performed on obese and diabetic rats. As a result, with a disrupted endothelin-1 axis, sham-operated subjects manifested a deteriorated endothelial function and increased risk of developing cancer compared to the healthy controls. However, far more than improving glycometabolism, SG reversed these negative effects by normalizing the endothelin-1 axis and reducing DNA damage, which contributed to the effects of SG ameliorating endothelial function and preventing lung cancer. |
| Publish Date |
2020-05-28 13:08 |
| Citation |
Ruze R, Xiong YC, Li JW, Zhong MW, Xu Q, Yan ZB, Zhu JK, Cheng YG, Hu SY, Zhang GY. Sleeve gastrectomy ameliorates endothelial function and prevents lung cancer by normalizing endothelin-1 axis in obese and diabetic rats. World J Gastroenterol 2020; 26(20): 2599-2617 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i20/2599.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i20.2599 |
