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Articles Published Processes
8/21/2020 6:42:51 AM | Browse: 721 | Download: 2069
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Received |
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2020-03-04 01:27 |
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Peer-Review Started |
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2020-03-04 01:30 |
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To Make the First Decision |
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Return for Revision |
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2020-04-25 16:33 |
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Revised |
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2020-06-07 07:06 |
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Second Decision |
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2020-07-17 09:14 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-07-18 04:57 |
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Articles in Press |
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2020-07-18 04:57 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-07-23 22:51 |
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Typeset the Manuscript |
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2020-08-20 00:38 |
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Publish the Manuscript Online |
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2020-08-21 06:42 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Clinical and prognostic significance of CC chemokine receptor type 8 protein expression in gastrointestinal stromal tumors
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Huai-Liang Li, Lin-Hua Wang, Yi-Lin Hu, Ying Feng, Xiao-Hong Li, Yi-Fei Liu, Peng Li, Qin-Sheng Mao and Wan-Jiang Xue |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Wan-Jiang Xue, FAASLD, BSc, MD, PhD, Chief Doctor, Professor, Department of Gastrointestinal Surgery, Nantong University Affiliated Hospital, No. 20 Xisi Street, Nantong 226001, Jiangsu Province, China. xuewanjiang@ntu.edu.cn |
| Key Words |
Gastrointestinal stromal tumors; CC chemokine receptor type 8; Malignant phenotype; Prognosis; STRING database; Immune regulation |
| Core Tip |
Although the application of c-kit inhibitors prolonged survival of the advanced gastrointestinal stromal tumor (GIST) patients, the prognosis was not optimistic. Because of the role in tumor immunity, chemokine receptors have been identified as independent prognostic factors in various cancers, but have not been investigated in GISTs. We evaluated CC chemokine receptor type 8 expression in GISTs by immunohistochemistry, and analyzed its relationships with clinicopathological features and prognosis. We also investigated its role in tumor immunity using the STRING database. These confirmed that CC chemokine receptor type 8 can be used as an independent prognostic factor for GISTs, and even as a potential therapeutic target. |
| Publish Date |
2020-08-21 06:42 |
| Citation |
Li HL, Wang LH, Hu YL, Feng Y, Li XH, Liu YF, Li P, Mao QS, Xue WJ. Clinical and prognostic significance of CC chemokine receptor type 8 protein expression in gastrointestinal stromal tumors. World J Gastroenterol 2020; 26(31): 4656-4668 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i31/4656.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i31.4656 |
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