Publication Name	World Journal of Gastroenterology
Manuscript ID	5519
Country	United Kingdom

Received	2013-09-12 09:32
Peer-Review Started	2013-09-12 17:01
To Make the First Decision	2013-10-22 16:11
Return for Revision	2013-10-23 18:55
Revised	2013-11-18 02:43
Second Decision	2013-12-03 21:15
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-12-04 06:44
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-01-24 17:08
Publish the Manuscript Online	2014-02-17 14:01

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Incidence and mortality of primary liver cancer in England and Wales: Changing patterns and ethnic variations
Manuscript Source	Invited Manuscript
All Author List	Nimzing G Ladep, Shahid A Khan, Mary ME Crossey, Andrew V Thillainayagam, Simon D Taylor-Robinson and Mireille B Toledano
Funding Agency and Grant Number
Corresponding Author	Dr. Mireille B Toledano, MRC-HPA Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, St Mary’s Campus, Norfolk Place, London, W2 1PG, United Kingdom. m.toledano@imperial.ac.uk
Key Words	Primary liver cancer; Hepatocellular carcinoma; Intrahepatic bile duct; England and Wales; Ethnicity
Core Tip	It has been widely reported that primary liver cancer (PLC) has a poor prognosis and is increasing in many industrialised countries. We highlight an ongoing increase in the incidence of PLC in England and Wales, rendering artefactual explanations for the increase ever less convincing and, for the first time, describe ethnic variability in the incidence. More widespread use of histology in the confirmation of PLC is being embarked upon in England and Wales. These findings suggest that more aggressive screening efforts would be beneficial in England and Wales so as to improve survival. Targeted prevention programmes, including vaccination of at-risk population may be worthwhile.
Publish Date	2014-02-17 14:01
Citation	Ladep NG, Khan SA, Crossey MME, Thillainayagam AV, Taylor-Robinson SD, Toledano MB. Incidence and mortality of primary liver cancer in England and Wales: Changing patterns and ethnic variations. World J Gastroenterol 2014; 20(6): 1544-1553
URL	http://www.wjgnet.com/1007-9327/full/v20/i6/1544.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i6.1544

Full Article (PDF)	WJG-20-1544.pdf
Full Article (Word)	WJG-20-1544.doc
Manuscript File	5519-Review.doc
Answering Reviewers	5519-Answering reviewers.pdf
Copyright License Agreement	5519-Copyright assignment.pdf
Peer-review Report	5519-Peer review(s).pdf
Scientific Editor Work List	5519-Scientific editor work list.doc