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Articles Published Processes
7/20/2020 2:28:50 AM | Browse: 708 | Download: 1302
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Received |
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2020-03-06 13:30 |
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Peer-Review Started |
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2020-03-06 13:33 |
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To Make the First Decision |
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Return for Revision |
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2020-04-26 22:02 |
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Revised |
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2020-05-24 14:40 |
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Second Decision |
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2020-05-27 10:06 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-05-28 21:52 |
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Articles in Press |
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2020-05-28 21:52 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-06-04 21:10 |
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Typeset the Manuscript |
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2020-07-17 05:57 |
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Publish the Manuscript Online |
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2020-07-20 02:28 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
Circulating cell-free nucleic acids as prognostic and therapy predictive tools for metastatic castrate-resistant prostate cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Navid Sobhani, Marianna Sirico, Daniele Generali, Fabrizio Zanconati and Bruna Scaggiante |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Lega Italiana per la Lotta contro i Tumori |
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| Beneficentia Stiftung |
2016/16 |
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| Corresponding Author |
Bruna Scaggiante, PhD, Assistant Professor, Department of Life Sciences, University of Trieste, Via Giorgeri 1, Trieste 34127, Italy. bscaggiante@units.it |
| Key Words |
Metastatic castrate-resistant prostate cancer; Circulating free deoxyribonucleic acid; Cell-free tumor deoxyribonucleic acid; Circulating free ribonucleic acid; Liquid biopsy; Prostate cancer |
| Core Tip |
Among men in industrialized countries, prostate cancer is the most frequent occurring type of cancer and the leading cause of cancer-related deaths. Due to anti-androgenic and antineoplastic therapies, the 5 years survival has increased but the metastatic castration-resistant prostate cancer (mCRPC) form is still hard to cure. The monitoring of mCRPC patients by prostate specific antigen is not enough, as about 25% of them has normal prostate specific antigen levels. To assure an optimal management of mCRPC patients, specific markers to monitor response to therapies and to predict the clinical outcomes are an urgent need. In this respect, it has been demonstrated that liquid biopsy on circulating cell-free deoxyribonucleic acid is able to give useful information about the genetic status of the tumor and the prognosis of mCRPC. Liquid biopsy on circulating cell-free deoxyribonucleic acid has been proved to reflect the heterogeneity of the tumor in the tissues, thus can be close to enter the clinical practice. Circulating cell-free ribonucleic acid molecules in liquid biopsy are emerging and interesting tools which can provide further improved molecular information on the mCRPC in response to therapies and indicate the tumor aggressiveness. In the future perspective, liquid biopsy on circulating cell-free nucleic acids has the potential to integrate clinical data for a personalized management of mCRPC patients. |
| Publish Date |
2020-07-20 02:28 |
| Citation |
Sobhani N, Sirico M, Generali D, Zanconati F, Scaggiante B. Circulating cell-free nucleic acids as prognostic and therapy predictive tools for metastatic castrate-resistant prostate cancer. World J Clin Oncol 2020; 11(7): 450-463 |
| URL |
https://www.wjgnet.com/2218-4333/full/v11/i7/450.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v11.i7.450 |
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